丁二磺酸腺苷蛋氨酸联合还原型谷胱甘肽治疗病毒性肝炎高胆红素血症的效果研究  

Study on the effect of ademetionine1,4-butanedisulfonate combined with reduced glutathione on the treatment of viral hepatitis with hyperbilirubinemia

作　　者：赵林[1] 童成民[1] 杨长河 ZHAO Lin;TONG Cheng-min;YANG Chang-he(Infection Department,The 941 Hospital of the Joint Service Support Force of the People's Liberation Army,Xining 810007,China)

机构地区：[1]中国人民解放军联勤保障部队第九四一医院感染科,810007

出　　处：《中国实用医药》2023年第16期97-100,共4页China Practical Medicine

摘　　要：目的研究丁二磺酸腺苷蛋氨酸联合还原型谷胱甘肽治疗病毒性肝炎高胆红素血症的效果。方法52例病毒性肝炎高胆红素血症患者,依照双盲法分为治疗组和对照组,每组26例。对照组患者使用丁二磺酸腺苷蛋氨酸进行治疗,治疗组患者在对照组基础上联合注射用还原型谷胱甘肽治疗。比较两组患者治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、直接胆红素(DBiL)、γ-谷氨酰转移酶(GGT)、总胆红素(TBiL)]、凝血酶原时间(PT)及治疗效果、不良反应发生率。结果治疗后,治疗组患者丙氨酸氨基转移酶(63.35±13.25)U/L、直接胆红素(35.48±3.52)μmol/L、γ-谷氨酰转移酶(63.38±21.17)U/L、总胆红素(39.95±14.12)μmol/L均低于对照组的(89.94±19.71)U/L、(49.65±8.63)μmol/L、(88.74±35.76)U/L、(67.41±17.32)μmol/L,差异具有统计学意义(P<0.05)。治疗组患者凝血酶原时间(12.76±2.33)s短于对照组的(15.61±2.28)s,差异具有统计学意义(P<0.05)。治疗组治疗总有效率96.15%高于对照组的69.23%,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(χ^(2)=0.354,P=0.552>0.05)。结论病毒性肝炎高胆红素血症患者使用丁二磺酸腺苷蛋氨酸联合还原型谷胱甘肽治疗效果十分理想,可明显改善患者的肝功能,且用药不良反应少,安全性较高,值得临床推广和应用。Objective To study the effect of ademetionine1,4-butanedisulfonate combined with reduced glutathione on the treatment of viral hepatitis with hyperbilirubinemia.Methods A total of 52 patients with viral hepatitis and hyperbilirubinemia were divided into treatment group and control group according to double-blind method,with 26 cases in each group.The control group was treated with ademetionine1,4-butanedisulfonate,and the treatment group was treated with reduced glutathione for injection based on the control group.Both groups were compared in terms of liver function indexes[alanine aminotrasferase(ALT),direct bilirubin(DBiL),γ-glutamyltransferase(GGT),total bilirubin(TBiL)],prothrombin time(PT)before and after treatment,therapeutic effect,and incidence of adverse reactions.Results After treatment,the treatment group had alanine aminotransferase of(63.35±13.25)U/L,direct bilirubin of(35.48±3.52)μmol/L,γ-glutamyltransferase of(63.38±21.17)U/L,and total bilirubin of(39.95±14.12)μmol/L,which were lower than those of(89.94±19.71)U/L,(49.65±8.63)μmol/L,(88.74±35.76)U/L,and(67.41±17.32)μmol/L in the control group,and the differences were statistically significant(P<0.05).The prothrombin time of(12.76±2.33)s in the treatment group was shorter than that of(15.61±2.28)s in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the treatment group was 96.15%,which was higher than that of 69.23%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ^(2)=0.354,P=0.552>0.05).Conclusion Ademetionine1,4-butanedisulfonate combined with reduced glutathione has an ideal effect in the treatment of viral hepatitis with hyperbilirubinemia,which can significantly improve the liver function of patients,and has few adverse reactions and high safety,which is worthy of clinical promotion and application.

关 键 词：病毒性肝炎 高胆红素血症 还原型谷胱甘肽 丁二磺酸腺苷蛋氨酸 

分 类 号：R512.6[医药卫生—内科学]