地屈孕酮与黄体酮胶丸治疗先兆流产的效果对比  

Comparison of clinical effect of dydrogesterone and progesterone capsules in the treatment of threatened abortion

作　　者：刘平平 LIU Ping-ping(th Hospital of the People's Liberation Army,Jinan 250031,China)

机构地区：[1]解放军第九六零医院南院,250031

出　　处：《中国实用医药》2023年第16期100-103,共4页China Practical Medicine

摘　　要：目的对比地屈孕酮与黄体酮胶丸治疗先兆流产的临床效果。方法100例先兆流产患者,随机分为常规组和实验组,每组50例。常规组采取黄体酮胶丸治疗,实验组采用地屈孕酮治疗。对比两组腰酸缓解时间、腹痛缓解时间、出血停止时间、治疗前后血清孕酮水平、保胎成功率、不良反应发生率。结果实验组腰酸缓解时间、腹痛缓解时间、出血停止时间分别为(5.41±1.21)、(6.42±1.22)、(8.24±2.45)d,均短于常规组的(7.24±2.32)、(9.56±2.12)、(11.45±2.35)d,差异有统计学意义(P<0.05)。治疗前,两组血清孕酮水平对比,差异无统计学意义(P>0.05)。治疗后,两组血清孕酮水平均显著高于本组治疗前,实验组血清孕酮水平(130.21±11.02)nmol/L高于常规组的(110.01±8.45)nmol/L,差异有统计学意义(P<0.05)。实验组保胎成功率94.00%(47/50)高于常规组的76.00%(38/50),差异有统计学意义(P<0.05)。且实验组不良反应发生率2.00%(1/50)低于常规组的20.00%(10/50),差异有统计学意义(P<0.05)。结论地屈孕酮治疗先兆流产患者效果确切,可改善患者孕酮水平,提高保胎成功率,降低不良反应发生率,其作用和安全性均优于黄体酮胶丸。Objective To compare the clinical effect of dydrogesterone and progesterone capsules in the treatment of threatened abortion.Methods A total of 100 patients with threatened abortion were randomly divided into conventional group and experimental group,with 50 cases in each group.The conventional group was treated with progesterone capsules,and the experimental group was treated with dydrogesterone.Both groups were compared in terms of remission time of soreness of waist,remission time of abdominal pain,time to stop bleeding,serum progesterone level before and after treatment,spuc success rate,and incidence of adverse reactions.Results The remission time of soreness of waist,remission time of abdominal pain and time to stop bleeding were(5.41±1.21),(6.42±1.22)and(8.24±2.45)d in the experimental group,which were shorter than those of(7.24±2.32),(9.56±2.12)and(11.45±2.35)d in the conventional group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in serum progesterone levels between the two groups(P>0.05).After treatment,the serum progesterone level in both groups was significantly higher than that before treatment in this group,and the serum progesterone level of(130.21±11.02)nmol/L in the experimental group was higher than that of(110.01±8.45)nmol/L in the conventional group.The differences were statistically significant(P<0.05).The spuc success rate of 94.00%(47/50)in the experimental group was than that of 76.00%(38/50)in the conventional group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions was 2.00%(1/50)in the experimental group,which was lower than that of 20.00%(10/50)in the conventional group,and the difference was statistically significant(P<0.05).Conclusion Dydrogesterone has a definite effect in the treatment of threatened abortion patients.It can improve the level of progesterone,increase the spuc success rate and lower the incidence of adverse reactions.Its effect and safety

关 键 词：先兆流产 地屈孕酮 黄体酮胶丸 临床效果 

分 类 号：R714.21[医药卫生—妇产科学]