小儿咽扁颗粒治疗小儿急性扁桃体炎疗效观察  

Observation on therapeutic effect of Xiaoer Yanbian Granules on children with acute tonsillitis

作　　者：沈斌娜 SHEN Bin-na(Fujian Province Zhao'an County Hospital,Zhangzhou 363500,China)

机构地区：[1]福建省诏安县医院,363500

出　　处：《中国现代药物应用》2023年第16期27-30,共4页Chinese Journal of Modern Drug Application

摘　　要：目的研究小儿急性扁桃体炎予以小儿咽扁颗粒治疗的应用价值。方法90例小儿急性扁桃体炎患儿为研究对象,依据治疗方式差异性分为观察组与对照组,各45例。对照组采用常规治疗,观察组采用小儿咽扁颗粒治疗。对比两组治疗效果、症状消失时间、炎症因子[血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-4(IL-4)]水平、中医症候积分及不良反应发生情况。结果观察组治疗总有效率97.78%高于对照组的80.00%,差异有统计学意义(P<0.05)。观察组退热时间、扁桃体缩小时间、咽痛缓解时间、充血消失时间分别为(2.05±0.24)、(2.67±0.32)、(3.82±0.68)、(3.02±0.85)d,均短于对照组的(2.74±0.16)、(3.08±1.14)、(4.74±0.52)、(3.38±0.65)d,差异有统计学意义(P<0.05)。干预后,观察组TNF-α(28.67±4.32)pg/ml、IL-1β(17.15±1.85)pg/ml、IL-4(36.39±7.19)ng/L均低于对照组的(41.08±6.14)pg/ml、(22.38±2.65)pg/ml、(44.08±7.25)ng/L,差异均有统计学意义(P<0.05)。干预后,观察组风热外袭、肺胃热盛中医症候积分分别为(8.12±2.78)、(9.41±2.55)分,均低于对照组的(10.05±3.27)、(11.33±5.32)分,差异均有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论在小儿急性扁桃体炎患儿治疗期间采用小儿咽扁颗粒治疗具有改善临床症状、缩短症状消失时间、降低中医症候积分及炎症因子水平的作用,且不良反应少,很大程度上提高了治疗效果,在临床中具有借鉴及应用推广价值。Objective To study the application value of Xiaoer Yanbian Granules on children with acute tonsillitis.Methods A total of 90 children with acute tonsillitis were divided into observation group and control group according to different treatment methods,with 45 cases in each group.The control group was treated with routine treatment,and the observation group was treated with Xiaoer Yanbian Granules.Both groups were compared in terms of therapeutic effect,symptom resolution time,inflammatory factor[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-4(IL-4)]levels,traditional Chinese medicine symptom score,and occurrence of adverse reactions.Results The total effective rate of the observation group was 97.78%,which was higher than that of 80.00%of the control group,and the difference was statistically significant(P<0.05).The time to fever reduction,tonsil reduction,sore throat relief,and congestion disappearance were(2.05±0.24),(2.67±0.32),(3.82±0.68),and(3.02±0.85)d in the observation group,which were shorter than those of(2.74±0.16),(3.08±1.14),(4.74±0.52),and(3.38±0.65)d in the control group,and the differences were statistically significant(P<0.05).After the intervention,the observation group had TNF-αof(28.67±4.32)pg/ml,IL-1βof(17.15±1.85)pg/ml,and IL-4 of(36.39±7.19)ng/L,which were lower than those of(41.08±6.14)pg/ml,(22.38±2.65)pg/ml,and(44.08±7.25)ng/L in the control group,and the differences were statistically significant(P<0.05).After the intervention,the traditional Chinese medicine symptom scores of wind-heat external attack and exuberant lung-stomach heat in the observation group were(8.12±2.78)and(9.41±2.55)points,which were lower than those of(10.05±3.27)and(11.33±5.32)points in the control group,and the differences were all statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion During the treatment of children with acute tonsillitis,Xiaoer Yanbian Granules

关 键 词：小儿急性扁桃体炎 小儿咽扁颗粒 治疗效果 不良反应 炎性指标 

分 类 号：R276.1[医药卫生—中医五官科学]