急性心肌梗死介入术后应用阿托伐他汀早期强化治疗的效果观察  

Effect observation of early intensive treatment with atorvastatin in patients after acute myocardial infarction intervention

作　　者：龙志锋 LONG Zhi-feng(First Department of Internal Medicine,Sihui People's Hospital,Sihui 526200,China)

机构地区：[1]广东省四会市人民医院内一科,526200

出　　处：《中国现代药物应用》2023年第16期110-112,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究急性心肌梗死(AMI)患者介入术后应用阿托伐他汀早期强化治疗的效果。方法112例AMI介入术后患者,随机分为观察组(58例)和对照组(54例)。观察组介入术后应用40 mg/d阿托伐他汀早期强化治疗,对照组介入术后应用20 mg/d阿托伐他汀治疗。对比两组患者的临床疗效、不良反应发生率及治疗前后心功能指标[心肌肌钙蛋白I(cTnI)、脑钠肽(BNP)、左室射血分数(LVEF)]。结果观察组治疗总有效率为94.83%,高于对照组的81.48%,差异有统计学意义(P<0.05)。治疗前,两组cTnI、BNP、LVEF对比差异无统计学意义(P>0.05);治疗后,两组cTnI、BNP、LVEF均优于治疗前,且观察组cTnI(0.74±0.36)ng/ml、BNP(56.26±11.66)pg/ml、LVEF(55.86±10.54)%均优于对照组的(0.92±0.40)ng/ml、(61.22±12.82)pg/ml、(47.02±12.69)%,差异有统计学意义(P<0.05)。观察组不良反应发生率10.34%与对照组的7.41%对比,差异无统计学意义(P>0.05)。结论AMI介入术后患者应用阿托伐他汀早期强化治疗能在确保安全的基础上提升临床疗效,改善患者的心功能,值得推荐。Objective To study the effect of early intensive treatment with atorvastatin in patients after acute myocardial infarction(AMI)intervention.Methods A total of 112 patients after AMI intervention were randomly divided into observation group(58 cases)and control group(54 cases).The observation group received early intensive treatment with 40 mg/d atorvastatin after intervention,and the control group received 20 mg/d atorvastatin after intervention.Both groups were compared in terms of clinical efficacy,incidence of adverse reactions and cardiac function indexes[cardiac troponin I(cTnI),brain natriuretic peptide(BNP),left ventricular ejection fraction(LVEF)]before and after treatment.Results The total effective rate of the observation group was 94.83%,which was higher than that of 81.48%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in cTnI,BNP and LVEF between the two groups(P>0.05).After treatment,cTnI,BNP and LVEF in both groups were better than those before treatment in this group;the observation group had cTnI of(0.74±0.36)ng/ml,BNP of(56.26±11.66)pg/ml and LVEF of(55.86±10.54)%,which were better than those of(0.92±0.40)ng/ml,(61.22±12.82)pg/ml and(47.02±12.69)%in the control group;the differences were statistically significant(P<0.05).The incidence of adverse reactions of the observation group and the control group were 10.34%and 7.41%,and the difference between the two groups was not statistically significant(P>0.05).Conclusion The early intensive treatment with atorvastatin in patients after AMI intervention can improve clinical efficacy and cardiac function on the basis of ensuring safety,and is worthy of recommendation.

关 键 词：急性心肌梗死 介入术 阿托伐他汀 早期强化 心功能 

分 类 号：R542.22[医药卫生—心血管疾病]