青龙辟秽汤治疗小儿轻型新型冠状病毒奥密克戎变异株感染的临床研究  

Clinical Study of Qinglong Pihui Decoction in the Treatment of Children with Mild Novel Coronavirus Omicron Variant Infection

作　　者：董玲[1] 卢慧娜[1] 赵雪晴[1] 何素蓉[1] 杨明明 Dong Ling;Lu Huina;Zhao Xueqing;He Surong;Yang Mingming(Chongqing Hos-pital of Traditional Chinese Medicine,Chongqing 400021,China)

机构地区：[1]重庆市中医院,重庆400021

出　　处：《中国中医急症》2023年第8期1364-1367,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81904255);重庆市科卫联合医学科研项目(2021MSXM317)。

摘　　要：目的观察青龙辟秽汤治疗小儿轻型新型冠状病毒奥密克戎变异株感染的临床疗效。方法将100例轻型新型冠状病毒奥密克戎变异株感染患儿按随机数字表法分为对照组与治疗组各50例,对照组给予口服九味羌活颗粒,治疗组予口服青龙辟秽汤,两组均治疗5 d。比较两组患儿临床有效率、治疗前后症状改善情况、治疗前后中医证候积分情况。结果治疗组总有效率高于对照组(P<0.05);治疗组患儿体温复常时间,头身疼痛、咽痛消失时间,干咳少痰及肢体困倦缓解时间均短于对照组(P<0.05)。两组治疗后主要症状、次要症状中医证候积分均较治疗前有所下降(P<0.05)。治疗组治疗后上述中医证候积分均低于对照组(P<0.05)。两组治疗后白细胞计数/淋巴细胞计数(NLR)、血清淀粉样蛋白(SAA)均低于治疗前(P<0.05)。治疗组治疗后的NLR、SAA均低于对照组(P<0.05)。两组C反应蛋白(CRP)分别于治疗前后均无明显变化(P>0.05)。两组患儿在治疗过程中均未出现因口服药物而导致的严重胃肠道不适、皮疹等不良反应。结论青龙辟秽汤可能具有抗病毒、降低炎性反应、调节患儿免疫状态的作用,同时可在短时间内改善患儿症状、阳性体征且安全性良好。Objective:To observe the clinical efficacy of Qinglong Pihui Decoction in the treatment of mild novel coronavirus omicron variant infection.Methods:Children with mild novel coronavirus omicron variant were collected and divided into experimental group and control group by random number table method.A total of 100 patients were included ultimately,with 50 in the experimental group and 50 in the control group.The control group was treated with Jiuwei Qianghuo Granules,and the experimental group was treated with Qinglong Pihui Decoction.Both groups were treated for 5 d.The clinical response rate,the improvement of symptoms before and after treatment,and the change of TCM syndrome score before and after treatment were compared.Results:The total response rate was higher in the experimental group than that in the control group(P<0.05).In the experimen⁃tal group,the time of temperature recovery,head and body pain and the disappearance time of sore throat,dry cough and limb sleepiness were shorter than that in the control group(P<0.05).In both groups,the score of TCM symptoms decreased compared with before treatment(P<0.05).After treatment,the above TCM syndrome scores of the experimental group were lower than those of the control group(P<0.05).The levels of NLR and SAA in both groups were lower after treatment than before treatment(P<0.05),and levels in the experimental group were lower than those in the control group(P<0.05).There was no significant change in CRP before and after treat⁃ment in both groups(P>0.05).Children in both groups had no adverse reactions such as severe gastrointestinal discomfort and rash caused by oral medication during the treatment.Conclusion:Qinglong Pihui Decoction may have the role of antiviral,reducing inflammatory response,regulating the immune status of children,which can improve the symptoms and signs of children in a short time with good safety.

关 键 词：新型冠状病毒 奥密克戎变异株 小儿 青龙辟秽汤 

分 类 号：R511[医药卫生—内科学]