地黄饮子联合穴位针刺对急性脑梗死患者神经功能及脑氧代谢的影响  

Effects of Dihuang Yinzi Decoction combined with Acupoint Acupuncture on Neurological Function and Cerebral Oxygen Metabolism in Acute Cerebral Infarction

作　　者：孙龙[1] 王革生[2] 吴彦青[3] Sun Long;Wang Gesheng;Wu Yanqing(Beijing Huairou Hospital of Traditional Chinese Medicine,Beijing 101400,China)

机构地区：[1]北京市怀柔区中医医院,北京101400 [2]北京中医药大学东方医院,北京100078 [3]首都医科大学附属北京中医医院,北京100010

出　　处：《中国中医急症》2023年第8期1443-1446,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81873114)。

摘　　要：目的观察地黄饮子联合穴位针刺对急性脑梗死患者神经功能恢复、脑氧代谢及美国国立卫生研究院卒中量表(NIHSS)评分的影响。方法选取106例患者按随机数字表法分为对照组与观察组各53例,对照组采用地黄饮子治疗,观察组在此基础上加用穴位针刺,观察两组临床疗效、中医证候积分、神经功能恢复情况、脑灌注量以及脑氧代谢差异。结果观察组总有效率为90.57%,显著高于对照组的75.47%(P<0.05);观察组治疗后半身不遂、肢体僵硬等各项中医证候积分均低于对照组(P<0.05);观察组治疗后NIHSS评分低于对照组(P<0.05);观察组治疗后脑血容量和脑血流量高于对照组(P<0.05),平均通过时间短于对照组(P<0.05);观察组治疗后动脉血氧含量、动静脉血氧含量差以及脑氧摄取率均低于对照组(P<0.05);两组不良反应率差异无统计学意义(P>0.05)。结论地黄饮子联合穴位针刺治疗能促进急性脑梗死患者神经功能恢复,改善脑灌注和脑氧代谢,临床疗效较显著。Objective:To explore the effects of combination of Dihuang Yinzi Decoction and acupoint acupunc⁃ture on neurological function recovery,cerebral oxygen metabolism and National Institutes of Health Stroke Scale(NIHSS)score in the treatment of patients with acute cerebral infarction.Methods:106 patients with acute cerebral infarction were divided into control group(53 cases)and observation group(53 cases)according to the random number table method.The control group was treated with Dihuang Yinzi Decoction while the observation group was additionally given acupoint acupuncture on this basis.The differences in clinical efficacy,TCM symp⁃toms scores,neurological function recovery,cerebral perfusion volume and cerebral oxygen metabolism were observed in the two groups.Results:After treatment,the total clinical effective rate was 90.57%in observation group,which was significantly higher than 75.47%in control group(P<0.05).After treatment,the scores of vari⁃ous TCM symptoms such as hemiplegia and limb stiffness in observation group were lower than those in control group(P<0.05).The NIHSS score of observation group after treatment was lower compared with that of control group(P<0.05).The cerebral blood volume and cerebral blood flow after treatment were higher in observation group than those in control group(P<0.05),and the mean transit time was shorter than that in control group(P<0.05).The arterial oxygen content,arterio-venous oxygen content difference and cerebral oxygen extraction rate in observation group were lower compared to control group after treatment(P<0.05).There was no statistical difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion:Dihuang Yinzi Decoction combined with acupoint acupuncture therapy can promote the recovery of neurological function and improve the cerebral perfusion and cerebral oxygen metabolism in patients with acute cerebral infarction,and it has a significant clinical efficacy.

关 键 词：急性脑梗死 地黄饮子 穴位针刺 神经功能 血流动力学 脑氧代谢 

分 类 号：R743.9[医药卫生—神经病学与精神病学]