河南省MSM中HIV暴露后预防及时情况及相关因素  

The situation of timely HIV post-exposure prophylaxis in MSM and its influencing factors in Henan Province

作　　者：王奇[1] 施建春 徐亚珂 崔艳 李超峰[2] 朱新朋[1] 张国龙 赵东阳[1] WANG Qi;SHI Jianchun;XU Yake;CUI Yan;LI Chaofeng;ZHU Xinpeng;ZHANG Guolong;ZHAO Dongyang(Institute of STD and AIDS Prevention and Control,Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016,Henan,China;The Sixth People's Hospital of Zhengzhou,Zhengzhou 450015,Henan,China)

机构地区：[1]河南省疾病预防控制中心,郑州450016 [2]郑州市第六人民医院,郑州450015

出　　处：《中国艾滋病性病》2023年第7期800-803,共4页Chinese Journal of Aids & STD

基　　金：河南省医学科技攻关计划(202102310461)。

摘　　要：目的 了解河南省采取HIV的nPEP的MSM行为特征及预防及时性,分析预防及时性的有关影响因素。方法 对河南省HIV暴露前后预防试点门诊接诊的MSM进行咨询及适用性评估,收集人群的一般人口学特征、性行为特征、药物预防服务、实验室检测、知识知晓及阻断等情况,采用单因素及多因素Logistic回归对影响及时预防的因素进行分析。结果 试点门诊自2021年1月至2022年12月共对229名MSM开展了nPEP服务,其中未婚153人(66.8%)、30岁以下136人(59.4%)、大学以上154人(67.2%),94.3%高危行为发生地为本地,81.7%通过互联网交友,34.5%性伴HIV阳性,8.7%全程规范使用安全套,暴露者在24 h内及时获取到药物预防服务比例为65.5%,暴露者4周及12周HIV检测均阴性,多因素分析显示高危行为发生在外地(0R=10.731,95%CI:2.259~20.935)是及时接受nPEP的危险因素,通过医生面对面获取nPEP知识(0R=0.468,95%CI:0.219~0.902)是其保护因素。结论 河南省接受nPEP服务的MSM,其无保护性行为比例及性伴感染比例均较高;面对面咨询干预对提高暴露后预防及时性至关重要。Objective To understand the behavioral characteristics and prevention timeliness of HIV nonoccupational post-exposure prophylaxis(nPEP)among MSM in Henan Province,and analyze the relevant factors of timely prevention.Methods A face-to-face counseling survey and applicability assessment were carried out among MSM in HIV pre/post-exposed prophylaxis pilot outpatient clinics in Henan Province,and the data of general demographic characteristics,high-risk behavior characteristics,sexual behavior characteristics,drug prophylaxis services,laboratory testing,knowledge awareness,and nPEP situation were collected.Single-and multi-factor logistic regression were used to analyze the factors affecting prevention timeliness.Results From January 2021 to December 2022,a total of 229 MSM had received nPEP service,including 153 unmarried individuals(66.8%),136 individuals under 30 years old(59.4%),154 individuals were university degree or above(67.2%).Among the MSM,94.3%of high-risk behaviors occurred locally,81.7%sought sexual partners through internet Apps,34.5%had HIV positive sexual partners,8.7%used condom correctly during the whole process,65.5%obtained nPEP within 24 h.The HIV test results of exposed MSM were all negative after 4 and 12 weeks.The multivariate analysis showed that the high-risk behavior occurred nonlocal(OR=10.731,95%CI:2.259-20.935)was the risk factor of nPEP timeliness,while the knowledge awareness acquired from doctors'face-to-face consultation was the protective factor(OR=0.468,95%CI:0.219-0.902).Conclusions Among MSM received nPEP service in Henan Province,the proportion of unprotected sexual behaviors and sexual partners with HIV positive was high.Face to face counseling is crucial for improving the nPEP timeliness.

关 键 词：艾滋病 男男性行为者 暴露后预防 及时性 

分 类 号：R373.9[医药卫生—病原生物学]