唐山地区体检人群甲状腺功能情况调查及对血脂、血糖、25(OH)D的影响  

Investigation on thyroid function of physical examination population in Tangshan area and its influence on blood lipids, blood glucose, and 25 (OH) D

作　　者：郑贺 彭英明 张颖根 袁丽杰 孔稳 李宏芬[1] Zheng He;Peng Yingming;Zhang Yinggen;Yuan Lijie;Kong Wen;Li Hongfen(Department of Nuclear Medicine,Kailuan General Hospital,Tangshan 063000,China;Department of Cardiothoracic Surgery,Kailuan General Hospital,Tangshan 063000,China)

机构地区：[1]开滦总医院核医学科,唐山063000 [2]开滦总医院心胸外科,唐山063000

出　　处：《中国医师杂志》2023年第8期1194-1198,共5页Journal of Chinese Physician

基　　金：河北省医学科学研究课题计划(20221585)。

摘　　要：目的了解唐山地区体检人群甲状腺功能情况,分析甲状腺功能对血脂、空腹血糖(FPG)及血清25-羟维生素D[25(OH)D]的影响。方法选取2020年6月至2021年6月在开滦总医院进行体检的唐山地区人群为研究对象,检测其甲状腺血清学指标[促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、三碘甲状腺原氨酸(TT3)及甲状腺激素(TT4)]水平,按照甲状腺功能分为正常组、甲亢组、甲减组、亚临床甲亢组、亚临床甲减组,对比不同亚组的血脂指标[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、FPG及25(OH)D水平,采用Pearson相关分析TSH水平与血脂、FPG及25(OH)D水平的相关性。结果本次从唐山地区体检人群中选取研究对象2884例,甲状腺功能异常人群占比12.03%(347/2884),其中亚临床甲状腺功能异常人群占总甲状腺功能异常人群比例达80.69%(280/347)。随着年龄增长,男性在21~<30岁、30~<40岁、40~<50岁、≥50岁年龄组中甲状腺功能异常比例分别为5.06%(4/79)、7.52%(33/439)、8.91%(53/595)、9.95%(66/663),女性上述年龄组中甲状腺功能异常比例为14.02%(15/107)、15.06%(61/405)、15.47%(67/433)、29.45%(48/163)。甲亢组血清TG、TC、LDL-C、25(OH)D低于正常组,HDL-C、FPG高于正常组,差异有统计学意义(均P<0.05)。甲减组血清TG、TC高于正常组,FPG、25(OH)D低于正常组,差异有统计学意义(均P<0.05)。TSH水平与TC、LDL-C呈正相关,与FPG、25(OH)D呈负相关(均P<0.05)。结论唐山地区甲状腺功能异常人群以亚临床甲状腺功能异常症为主,TSH水平与血脂、空腹血糖及血清25(OH)D水平具有一定相关性。Objective To understand the thyroid function of the physical examination population in Tangshan area,and analyze the effects of thyroid function on blood lipids,fasting blood glucose(FPG),and serum 25 hydroxyvitamin D[25(OH)D].Methods A population from the Tangshan area who underwent physical examinations at the Kailuan General Hospital from June 2020 to June 2021 was selected as the study subjects and the levels of their thyroid serological indicators[thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4),triiodothyronine(TT3),and thyroid hormone(TT4)]were tested.According to thyroid function,they were divided into normal group,hyperthyroidism group,hypothyroidism group,subclinical hyperthyroidism group,and subclinical hypothyroidism group.We compared the blood lipid indicators[triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)],FPG,and 25(OH)D levels in different subgroups,and the Pearson correlation analysis was used to investigate the correlation between TSH levels and blood lipids,FPG,and 25(OH)D levels.Results In this study,2884 subjects were selected from the physical examination population in Tangshan area.The proportion of people with abnormal thyroid function was 12.03%(347/2884),among which the proportion of subclinical thyroid function abnormal population in the total thyroid function abnormal population was 80.69%(280/347).As men age,the proportion of thyroid dysfunction in the age groups of 21-<30 years old,30-<40 years old,40-<50 years old,and≥50 years old was 5.06%(4/79),7.52%(33/439),8.91%(53/595),and 9.95%(66/663),respectively.The proportion of thyroid dysfunction in the above age group of women was 14.02%(15/107),15.06%(61/405),15.47%(67/433),and 29.45%(48/163).The serum TG,TC,LDL-C,and 25(OH)D levels in the hyperthyroidism group were lower than those in the normal group,while HDL-C and FPG levels were higher than those in the normal group,with statistically significant differences(all P<0.05)

关 键 词：甲状腺激素类 甘油三酯类 胆固醇 血糖 25-羟维生素D 

分 类 号：R581[医药卫生—内分泌]