纤维肌痛综合征实验室相关诊断指标的研究进展  

Recent advance in laboratory-related indicators of fibromyalgia syndrome

作　　者：匡思诗 蔡华 高明昕[1] 刘昱璐 陶金[2] 郑婷婷 张园[1] Kuang Sishi;Cai Hua;Gao Mingxin;Liu Yulu;Tao Jin;Zheng Tingting;Zhang Yuan(Department of Geriatrics,Second Hospital of Soochow University,Soochow 215000,China;School of Basic Medicine and Biological Sciences,School of Medicine of Soochow University,Soochow 215000,China;Department of Geriatrics,Division of Preventive Health Care,Second Hospital of Soochow University,Soochow 215000,China)

机构地区：[1]苏州大学附属第二医院老年医学科,苏州215000 [2]苏州大学苏州医学院基础医学与生物科学学院,苏州215000 [3]苏州大学附属第二医院预防保健处,苏州215000

出　　处：《中华神经医学杂志》2023年第6期642-647,共6页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金面上项目(82271245、81671080);苏州大学省级重点实验室开放课题(KJS1921);苏州大学临床神经疾病中心课题(ND2022B03)。

摘　　要：纤维肌痛综合征(FMS)又叫纤维肌痛症,临床表现为弥漫性慢性肌肉及骨骼疼痛,并伴有疲劳、睡眠障碍、抑郁发作以及认知和肠道功能障碍。由于缺乏明确的特异性实验室指标及适当的影像学检查,FMS的诊断多基于临床症状,但FMS的临床症状又缺乏特异性,目前的临床诊断标准多为排他性标准,因而容易出现漏诊和误诊。为进一步推动FMS的规范化诊断和治疗,本文围绕国内外FMS的实验室相关诊断指标[如Tau蛋白、脂联素、血清组织蛋白酶S(CatS)和胱抑素C、血清铁蛋白、一氧化氮、中性粒细胞/淋巴细胞比率(NLR)、血小板分布宽度(PDW)和平均血小板体积(MPV)等]的研究进展进行综述,旨在为FMS患者的早期诊断及干预提供新思路。Fibromyalgia syndrome(FMS),also known as fibromyalgia,is clinically characterized by diffuse chronic muscle and bone pain,accompanied by fatigue,sleep disturbances,depressive episodes,and cognitive and intestinal dysfunction.Due to lack of clear specific laboratory indicators and appropriate imaging examinations,FMS diagnosis is mostly based on clinical symptoms,but FMS clinical symptoms of lack specificity,and current clinical diagnostic criteria are mostly exclusive criteria,which is prone to missed diagnosis and misdiagnosis.In order to further promote the standardized diagnosis and treatment of FMS,this paper makes extensive references to laboratory-related diagnostic indexes of FMS(Tau,adiponectin,serum cathepsin S,cystatin C,serum ferritin,nitric oxide,neutrophil/lymphocyte ratio,platelet distribution width and mean platelet volume)at home and abroad,aiming to provide new ideas for early diagnosis and intervention of FMS.

关 键 词：纤维肌痛综合征 实验室指标 TAU蛋白 脂联素 

分 类 号：R685[医药卫生—骨科学]