轻型方治疗新型冠状病毒奥密克戎变异株感染轻型患者临床研究  

Clinical Study on the Efficacy of Qingxing Formula(轻型方) in Treatment of Mild Patients Infected with SARS-CoV-2 Omicron Variant

作　　者：陆聆韵[1] 郑岚[1] 张惟郁[1] 吕玲玲[1] 李琼 郑炜华[1] 杨翠萍 李勇[1] LU Lingyun;ZHENG Lan;ZHANG Weiyu;LYU Lingling;LI Qiong;ZHENG Weihua;YANG Cuiping;LI Yong(Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院,上海200025

出　　处：《山东中医杂志》2023年第9期963-968,共6页Shandong Journal of Traditional Chinese Medicine

基　　金：上海市卫生健康委员会中医药防治新冠肺炎紧急科研立项项目(编号:XGYJKY2022-0306);上海市卫生健康委员会综合医院新冠肺炎中西医协作救治应急专项(编号:KY2023530)。

摘　　要：目的:比较轻型方与痰热清胶囊、连花清瘟胶囊治疗新型冠状病毒奥密克戎变异株感染轻型患者临床疗效。方法:纳入新型冠状病毒奥密克戎变异株感染轻型患者150例,根据倾向性评分法以1∶1∶1匹配,分为轻型方组、痰热清组、连花清瘟组各50例。通过问卷星进行中医临床症状的收集,对比分析3组患者的中医证候评分及临床疗效,比较3组患者的转阴时间及转阴率。结果:治疗后3组患者乏力、鼻塞流涕、咽痛、咳嗽证候评分均较治疗前降低,差异有统计学意义(P<0.01或P<0.05)。治疗后轻型方组、痰热清组气喘评分较治疗前降低,差异有统计学意义(P<0.01);连花清瘟组气喘评分与治疗前比较,差异无统计学意义(P>0.05)。治疗后轻型方组咽痛评分低于痰热清组,差异有统计学意义(P<0.05)。3组治疗后中医证候评分总分均较本组治疗前降低,差异有统计学意义(P<0.01);3组治疗后中医证候评分总分比较,差异无统计学意义(P>0.05)。轻型方组转阴天数最短,其次为痰热清组,连花清瘟组转阴天数最长;轻型方组转阴天数与连花清瘟组比较,差异有统计学意义(P<0.05)。轻型方组14 d阴转率94%,高于痰热清组88%与连花清瘟组56%,差异有统计学意义(P<0.001)。轻型方组、痰热清组和连花清瘟组治疗有效率分别为90%、86%和80%,3组比较差异无统计学意义(P>0.05)。结论:与痰热清胶囊、连花清瘟胶囊比较,轻型方能提高新型冠状病毒奥密克戎变异株感染轻型患者的转阴率,缩短转阴天数,可阻止病情进一步加重,从而降低死亡风险。Objective:To compare the therapeutic effect of Qingxing Formula(轻型方),Tanreqing Capsule(痰热清胶囊)and Lianhua Qingwen Capsule(连花清瘟胶囊)in the treatment of mild patients infected with SARS-CoV-2 Omicron variant.Methods:A total of 150 mild patients infected with SARS-CoV-2 Omicron variant were included and divided into Qingxing Formula group,Tanreqing group and Lianhua Qingwen group,with 50 cases in each group according to the propensity scoring method,the matching was 1∶1∶1.The clinical symptoms of traditional Chinese medicine(TCM)were collected by the questionnaire star,and the TCM syndrome scores and clinical efficacy of the three groups of patients were compared and analyzed,and the conversion time and conversion rate of the three groups were compared.Results:After treatment,the syndrome scores of feeble,nasal congestion,nasal discharge,sore throat and cough in three groups were lower than those before treatment,and the difference was statistically significant(P<0.01 or P<0.05).After treatment,the asthma score of Qingxing Formula group and Tanreqing group were lower than that before treatment,and the difference was statistically significant(P<0.01),while the asthma score of Lianhua Qingwen group was not statistically significant compared with that before treatment(P>0.05).After treatment,the syndrome scores of sore throat in the Qingxing Formula group was lower than that in the Tanreqing group,and the difference was statistically significant(P<0.05).The total scores of traditional Chinese medicine syndromes in three groups after treatment were lower than those before treatment,and the difference was statistically significant(P<0.01).After treatment,there was no statistically significant difference in the total scores of traditional Chinese medicine syndromes among the three groups(P>0.05).The negative conversion days in Qingxing Formula group were the shortest,which was followed by Tanreqing group,and those of the Lianhua Qingwen group were the longest.There was statistical significance

关 键 词：奥密克戎变异株 新型冠状病毒感染 轻型方 连花清瘟胶囊 痰热清胶囊 转阴率 转阴天数 

分 类 号：R256.1[医药卫生—中医内科学]