柴胡牡蛎汤加味治疗带状疱疹急性期肝经郁热证疗效观察  

Efficacy observation of Chaihu Muli decoction in the treatment of acute herpes zoster with syndrome of stagnated heat of liver meridian

作　　者：孙一平 杨素清[2] 安月鹏[2] 王宇[3] SUN Yiping;YANG Suqing;AN Yuepeng;WANG Yu(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院皮肤科,黑龙江哈尔滨150040 [3]解放军总医院第七医学中心皮肤科,北京100010

出　　处：《陕西中医》2023年第9期1220-1222,1226,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81973846)。

摘　　要：目的:探讨柴胡牡蛎汤加味治疗带状疱疹急性期肝经郁热证患者的疗效以及对患者血清白细胞介素(IL)-6与IL-8水平的影响。方法:选择状疱疹急性期肝经郁热证患者82例,根据随机数字表法分入对照组与治疗组,均选入41例。对照组予阿昔洛韦片;治疗组阿昔洛韦用法同对照组,并予柴胡牡蛎汤加味内服。两组治疗10 d。比较两组疼痛评分、主要症状消退时间、治疗效果以及血清IL-6与IL-8水平。结果:治疗10 d后,两组疼痛视觉模拟量表(VAS)评分明显减少,并且治疗组VAS评分减少更加显著(P<0.05);治疗组患者的止疱、疼痛缓解、结痂、脱痂的消退时间较对照组均显著缩短(P<0.05);治疗组与对照组的总有效率对应92.68%、73.17%,差异有统计学意义(P<0.05);治疗10 d后,两组患者血清IL-6与IL-8水平显著下调,且治疗组下调更明显(P<0.05)。结论:柴胡牡蛎汤加味治疗带状疱疹急性期肝经郁热证的疗效确切,可有效减轻患者的疼痛,缩短主要症状恢复时间,降低血清IL-6、IL-8水平。Objective:To investigate the efficacy of Chaihu Muli decoction in the treatment of acute herpes zoster with syndrome of stagnated heat of liver meridian and its effect on serum levels of interleukin(IL)-6 and IL-8.Methods:A total of 82 acute herpes zoster patients with syndrome of stagnated heat of liver meridian were selected and divided into control group and treatment group by referring to random number table method with 41 cases in each group.The control group was given acyclovir tablets,and the treatment group was treated with acyclovir the same as the control group and Chaihu Muli decoction.The two groups were treated for 10 days.The pain scores,time to resolution of major symptoms,therapeutic effects,and serum levels of IL-6 and IL-8 were compared between the two groups.Results:After treatment the visual analog scale(VAS)score of the two groups was significantly decreased,and the VAS score of the treatment group was significantly decreased(P<0.05).The specific time of blister,pain relief,scab and scab removal in treatment group was significantly shortened compared with control group(P<0.05).Total effective rate for treatment group and the control group was 92.68%and 73.17%,respectively,which was statistical significance between both groups(P<0.05).Post treatment,serum levels of IL-6 and IL-8 for both groups were evidently decreased,and the decrease for treatment group was evident(P<0.05).Conclusion:The efficacy of Chaihu Muli decoction in the treatment of acute herpes zoster with syndrome of stagnated heat of liver meridian is effective,which can effectively alleviate the pain of cases,shorten recovery time of main symptoms,and reduce the serum levels of IL-6 and IL-8.

关 键 词：带状疱疹 柴胡牡蛎汤 肝经郁热证 白细胞介素-6 白细胞介素-8 视觉模拟量表 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]