血小板源性生长因子在心血管系统疾病中的作用研究进展  

Research progress of platelet-derived growth factor in cardiovascular diseases

作　　者：谢继超 沈冲[2] 杨松 XIE Jichao;SHEN Chong;YANG Song(Department of Cardiology,Yixing Hospital,Jiangsu University,Yixing 214200,China)

机构地区：[1]江苏大学附属宜兴医院心血管内科,江苏宜兴214200 [2]南京医科大学,江苏南京211166

出　　处：《陕西医学杂志》2023年第9期1279-1280,F0003,共3页Shaanxi Medical Journal

基　　金：国家自然科学基金资助项目(82173611);江苏省宜兴市卫生健康委员会科研项目(2022-12)。

摘　　要：心血管疾病是我国老年人口生存质量降低的主要因素,也是对公众生命健康造成威胁的主要疾病之一。血小板源性生成因子(PDGF)及其受体(PDGFR)在心血管疾病中发挥着重要作用。随着研究的不断深入,PDGF和PDGFR在心血管疾病中的病理生理机制越发明朗,两者相互协同参与了心肌纤维化、动脉粥样硬化(AS)及心肌梗死等心血管疾病的发生与发展。现就PDGF在心血管疾病中的作用研究进展进行综述。Cardiovascular disease is the main factor that reduces the quality of life of the elderly population in China,and it is also one of the main diseases that pose a threat to public life and health.Platelet-derived growth factor(PDGF)and its receptor(PDGFR)play important roles in cardiovascular diseases.With the deepening of research,the pathophysiological mechanism of PDGF and PDGFR in cardiovascular diseases has been more and more invented,and the interaction between PDGF and PDGFR has participated in the occurrence and development of cardiovascular diseases such as myocardial fibrosis,atherosclerosis and myocardial infarction.This article reviews the research progress of PDGF in cardiovascular diseases.

关 键 词：心血管系统疾病 血小板源性生长因子 血小板源性生长因子受体 心肌纤维化 动脉粥样硬化 心肌梗死 

分 类 号：R714.252[医药卫生—妇产科学]