miRNA调控畜禽附睾生物功能的研究进展  

Research Progress on Regulation of Epididymis Biological Function by miRNA in Livestock and Poultry

作　　者：郭世浩 曹骏逸 盖凯 丛百林 刘一正 邢凯 陈俐[2] 盛熙晖[1] GUO Shi-Hao;CAO Jun-Yi;GAI Kai;CONG Bai-Lin;LIU Yi-Zheng;XING Kai;CHEN Li;SHENG Xi-Hui(College of Animal Science and Technology,Beijing University of Agriculture,Beijing 102206;College of Food Science and Engineering,Beijing University of Agriculture,Beijing 102206)

机构地区：[1]北京农学院动物科学技术学院,北京102206 [2]北京农学院食品科学与工程学院,北京102206

出　　处：《农业生物技术学报》2023年第9期1956-1964,共9页Journal of Agricultural Biotechnology

基　　金：现代农业产业技术体系-北京家禽创新团队(BJJQ-G11)。

摘　　要：公畜禽的繁殖性能和精液品质对畜牧生产具有重要意义,与母畜禽受胎率、产仔数、成活率等密切相关。附睾作为重要的繁殖器官,负责精子的浓缩、成熟(包括精子活力的获得和受精能力)、保护和储存。miRNA(microRNA)是一类长度约22 nt的非编码单链RNA分子,与畜禽附睾的一系列生理过程密切相关,参与调控精子活力、精子成熟、精子细胞凋亡、离子通道活性、铜离子解毒等在内的不同生物过程。本文总结了哺乳动物与禽类附睾组织结构和功能的异同,综述了miRNA在调控畜禽附睾中精子活力、成熟、细胞凋亡、离子转运等生物学功能研究进展,为miRNA在附睾中的调控机制研究和种公畜繁殖性能的遗传育种研究提供参考。The reproductive performance and semen quality of male livestock and poultry are of great significance to animal husbandry,and are closely related to the conception rate,litter size and survival rate of female livestock and poultry.As an important reproductive organ,the epididymis is responsible for sperm concentration,maturation(including sperm vitality acquisition and fertilization ability),protection and storage.MicroRNA(miRNA)is a kind of non coding single stranded RNA molecule with a length of about 22 nt,which is closely related to a series of physiological processes in epididymis of livestock and poultry.miRNA participates in regulating different biological processes,including sperm vitality,sperm maturation,sperm cell apoptosis,ion channel activity,copper ion detoxification,etc.This paper summarized the similarities and differences in the structure and function of epididymis between mammals and poultry,reviewed the research progress of miRNA in regulating sperm motility,maturation,ion transport and other biological functions in epididymis of livestock and poultry.This review provides reference for the research of miRNA regulation mechanism in epididymis and genetic breeding of breeding male reproductive performance.

关 键 词：畜禽 附睾 MIRNA 精子成熟 

分 类 号：S813.3[农业科学—畜牧学]