离子液体的设计及其在经皮药物递送中的应用  

Design of Ionic Liquids and Their Applications in Transdermal Drug Delivery

作　　者：杨晓钰 朱慧勇[1] 高强 王哲烽 何军[1] 罗华菲[1] YANG Xiaoyu;ZHU Huiyong;GAO Qiang;WANG Zhefeng;HE Jun;LUO Huafei(National Advanced Medical Engineering Research Center,China State Institute of Pharmaceutical Industry,Shanghai 201203;School of Pharmacy,Fudan University,Shanghai 201203)

机构地区：[1]中国医药工业研究总院医药先进制造国家工程研究中心,上海201203 [2]复旦大学药学院,上海201203

出　　处：《中国医药工业杂志》2023年第5期665-673,共9页Chinese Journal of Pharmaceuticals

摘　　要：离子液体是一种由有机阳离子和有机或无机阴离子形成的低温熔盐,熔点一般小于100℃。由于阴阳离子结构的可设计性以及生物相容性阴阳离子的出现,使离子液体的毒性降低,在药物递送中的相关研究增多。该研究简单介绍了离子液体的发展历程和设计原则,并总结了离子液体在经皮给药系统中的作用,如增加难溶性药物溶解度、改变生物膜的通透性、作为药物递送载体以及形成药物活性成分离子液体(API-ILs)等,最后概述离子液体的安全性和临床应用情况,并对其未来发展进行展望。Ionic liquids is a low-temperature subclass of molten salts formed by organic cations and organic or inorganic anions,and its melting point is generally less than 100℃.Due to the designability of its anion and cation structures and the emergence of biocompatible anions and cations,toxicity of ionic liquids has been reduced,and related researches on drug delivery based on ionic liquids are increased.This review briefly introduces the development and design principles of ionic liquids,and summarizes the roles of ionic liquids in transdermal drug delivery systems,such as increasing the solubility of poorly soluble drugs,changing the permeability of biofilms,acting as drug delivery carriers and forming active pharmaceutical ingredient-ionic liquids(API-ILs).Finally,the safety and clinical application of ionic liquids are summarized,and the future development is prospected.

关 键 词：离子液体 设计 经皮药物递送 应用 

分 类 号：R944.9[医药卫生—药剂学]