Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation  

作　　者：Alexander Stevens Yanxiang Cui Sakar Shivakoti Hong Zhou 

机构地区：[1]Department of Microbiology,Immunology and Molecular Genetics,University of Califomia,Los Angeles(UCLA),609 Charles E Young Dr E,Los Angeles,CA 90095,USA [2]California NanoSystems Institute,UCLA,570 Westwood Plaza Building 114/Mail Code:722710,Los Angeles,CA 90095,USA [3]Department of Chemistry and Biochemistry,UCLA,607 Charles E.Young Drive East|Box 951569,Los Angeles,CA 90095-1569,USA

出　　处：《Protein & Cell》2023年第7期546-550,共5页蛋白质与细胞（英文版）

基　　金：supported in part by grants from the National Institutes of Health(AI094386 to Z.H.Z.);A.S.received support from NIH Ruth L.Kirschtein National Research Service Award A1007323;We acknowledge the use of resource at the Electron Imaging Center for Nanomachines supported by UCLA and by instrumentation grants from NIH(1S10RR23057,1S100D018111 and U24GM116792);NSF(DBI-1338135 and DMR-1548924);at the UCLA AIDS Institute supported in part by UCLA-CDU CFAR(NIH AI152501)。

摘　　要：Dear Editor,Aquareovirus(ARV,Reoviridae)causes hemorrhagic disease in the economically important golden shiner and grass carp of America and China,respectively(Nason et al.,2000;Fang et al.,2005).Reoviridae members are characterized by endogenous transcription of their multipartite genomes within capsids of 1-3 layers and are further classified based on the presence(Spinareovirinae subfamily,9 genera)or absence(Sedoreovirinae subfamily,6 genera)of mRNA-capping turrets along the innermost layer(King et al.,2012).

关 键 词：MECHANISM ENDOGENOUS REOVIRUS 

分 类 号：Q2[生物学—细胞生物学]