两样本孟德尔随机化分析血脂与肌肉减少症的因果关系  

The causal relationship between blood lipids and muscle atrophy based on Mendelian randomization analysis of two samples

作　　者：彭志华 潘俊曦 冯庆辉 田天照 张胜 李安 蔡迎峰 Peng Zhihua;Pan Junxi;Feng Qinghui;Tian Tianzhao;Zhang Sheng;Li An;Cai Yingfeng(The Affiliated TCM Hospital of Guangzhou Medical University,Guangzhou 510000,Guangdong Province,China)

机构地区：[1]广州医科大学附属中医医院,广东省广州市510000

出　　处：《中国组织工程研究》2024年第23期3699-3703,共5页Chinese Journal of Tissue Engineering Research

基　　金：广东省中医药局中医药科研项目(20222182),项目负责人:彭志华。

摘　　要：背景:骨质疏松常伴有肌肉减少症的发生并增加摔倒骨折的风险。近年来的研究表明,脂质代谢与肌肉减少症之间存在密切关系。异常的脂质代谢可能对肌肉的生理功能和代谢产生直接的影响。目的:探究脂质代谢与肌肉减少症之间的关系,并使用孟德尔随机化方法来评估其因果关系。方法:使用孟德尔随机化方法探究低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和三酰甘油与肌肉量之间的因果关系;采用了全基因组关联研究的研究数据,并进行敏感性分析来验证结果的可靠性;采用肌肉量的近似指标作为结局指标,包括四肢瘦体质量和躯干瘦体质量。结果与结论:①结果发现,肌肉量与低密度脂蛋白胆固醇和三酰甘油存在负相关关系,而高密度脂蛋白胆固醇与肌肉量之间未发现相关性;②敏感性分析结果表明因果关系稳健;③通过孟德尔随机化方法,此次研究提供了低密度脂蛋白胆固醇和三酰甘油与肌肉量之间存在因果关系的证据,这一发现深化了脂质对肌肉减少症影响的理解,对于预防及治疗肌肉减少症和骨质疏松症具有重要的临床意义。BACKGROUND:Osteoporosis is often accompanied by sarcopenia and an increased risk of fractures from falls.Recent studies have indicated a close relationship between lipid metabolism and sarcopenia.Abnormal lipid metabolism may directly impact muscle physiological function and metabolism.OBJECTIVE:To investigate the relationship between lipid metabolism and sarcopenia and evaluate their causal relationship using Mendelian randomization.METHODS:Mendelian randomization was used to explore the causal relationship between low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,triglycerides,and muscle mass.Research data from genome-wide association studies were used and a sensitivity analysis was conducted to verify the reliability of the results.Approximate indicators of muscle mass,including trunk lean mass and appendicular lean mass,were used as outcome measures.RESULTS AND CONCLUSION:The study found a negative correlation of low-density lipoprotein cholesterol and triglycerides with muscle mass,while no correlation was observed between high-density lipoprotein cholesterol and muscle mass.The results of the sensitivity analysis indicated a robust causal relationship.Using Mendelian randomization,this study provides evidence of a causal relationship between low-density lipoprotein cholesterol and triglycerides and muscle mass.This finding deepens our understanding of the effects of lipids on sarcopenia and has important clinical implications for the prevention and treatment of sarcopenia and osteoporosis.

关 键 词：肌肉减少症 骨质疏松症 孟德尔随机化 脂质代谢 低密度脂蛋白胆固醇 高密度脂蛋白胆固醇 三酰甘油 肌肉量 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R685