电子灸对遗忘型轻度认知障碍患者海马亚区体积的影响  

Effect of electronic moxibustion on the volume of hippocampal subregion in patients with amnestic mild cognitive impairment

作　　者：石娇 李星捷[1,2] 柳奇奇 刘俊 袁旭[1,2] 陈尚杰[1,2] Shi Jiao;Li Xingjie;Liu Qiqi;Liu Jun;Yuan Xu;Chen Shangjie(The Second Affiliated Hospital of Shenzhen University,Shenzhen 518101,Guangdong Province,China;Shenzhen Baoan Hospital of Southern Medical Universi­ty,Shenzhen 518101,Guangdong Province,China;Hefei Second People's Hospital,Hefei 230011,Anhui Province,China)

机构地区：[1]深圳大学第二附属医院,广东省深圳市518101 [2]南方医科大学深圳宝安医院,广东省深圳市518101 [3]合肥市第二人民医院,安徽省合肥市230011

出　　处：《中国组织工程研究》2024年第20期3176-3181,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81973922),项目负责人:陈尚杰;广东省科技计划项目(2016A020215202),项目负责人:陈尚杰。

摘　　要：背景:目前有研究表明,电子灸可以改善遗忘型轻度认知障碍患者的记忆功能,然而其作用机制有待进一步研究。海马体积萎缩和功能连接受损是遗忘型轻度认知障碍的重要影像学标志物,电子灸是否可以调节遗忘型轻度认知障碍患者的海马亚区体积值得研究。目的:观察电子灸对遗忘型轻度认知障碍患者海马区体积的影响。方法:于2018-04-01/2019-01-31在深圳大学第二附属医院(深圳市宝安人民医院)及下属社区服务中心与下属的社区招募遗忘型轻度认知障碍患者40例,采用随机数字表法分为治疗组与对照组,每组20例。治疗组接受调神益智电子灸治疗(艾灸温度45℃,每次20 min,1次/d,每周5次),对照组接受安慰灸治疗,持续治疗8周。治疗前及治疗结束后,利用MRI扫描海马亚区体积,采用Rivermead行为记忆测验(RBMT)量表、简易精神状态检查(MMSE)量表与蒙特利尔认知评估(MoCA)量表评估患者的认知功能,并分析海马亚区体积与各量表评分的相关性。结果与结论:①治疗结束后,治疗组患者海马左侧旁下托与左侧海马-杏仁核移行区体积增加,对照组患者海马左侧旁下托与左侧海马-杏仁核移行区体积减少,两组间海马左侧旁下托与左侧海马-杏仁核移行区体积变化值比较差异有显著性意义(P<0.05);②与治疗前比较,治疗组患者治疗结束后的RBMT、MMSE、MoCA量表评分均升高(P<0.05),对照组患者治疗结束后的3个量表评分无明显变化(P>0.05);治疗组患者治疗结束后的RBMT、MMSE、MoCA量表评分均高于对照组(P<0.05);③Pearson相关分析结果显示,治疗组左侧旁下托体积变化与RBMT量表评分呈显著正相关(r=0.418,P=0.014);④结果表明,电子灸可以改善遗忘型轻度认知障碍患者的记忆力,其机制可能是调节海马亚区结构的可塑性。BACKGROUND:Current studies have shown that electronic moxibustion can improve memory function in amnestic mild cognitive impairment;however,its mechanism of action needs to be further investigated.The atrophy of hippocampal volume and impairment of functional connectivity are important imaging markers of amnestic mild cognitive impairment.Whether electronic moxibustion can regulate the volume of hippocampal subregion of partients with amnestic mild cognitive impairment is worth studying.OBJECTIVE:To observe the effect of electronic moxibustion on the volume of hippocampal subregions in patients with amnestic mild cognitive impairment.METHODS:Forty patients with amnestic mild cognitive impairment were recruited from April 1,2018 to January 31,2019 at the community service centers around the Second Affiliated Hospital of Shenzhen University(Baoan Hospital of Southern Medical University),Shenzhen,China.They were randomly divided into treatment group(n=20)and control group(n=20).The treatment group was treated with electronic moxibustion of regulating the mind and benefiting the intelligence,while the control group was treated with placebo moxibustion.Moxibustion was given at 45 oC,20 minutes each time,once a day,5 times a week,for 8 weeks in total.Memory evaluation using Rivermead behavioral memory test and magnetic resonance imaging scanning for detecting the hippocampal subregion volume were performed for each patient before and after treatment,and cognitive function of each patient was assessed using Montreal cognitive assessment and mini-mental state examination.Correlation of hippocampal subregion volumes with scores on each scale was analyzed.RESULTS AND CONCLUSION:After treatment,the volumes of the left parasubiculum and the left hippocampal-amygdala migrating area increased in the treatment group but decreased in the control group,and there was a significant difference between the two groups(P<0.05).Compared with the pretreatment data,the Rivermead behavioral memory test,Montreal cognitive assessment,and min

关 键 词：轻度认知障碍 静息态磁共振 海马亚区 调神益智 电子灸 艾灸 

分 类 号：R459.9[医药卫生—治疗学] R319[医药卫生—临床医学] R246.6