星点设计-响应曲面法优选归芪扶正颗粒最佳成型工艺研究  

Research on the Molding Process of Gui Qi Fu Zheng Granules by Central Composite Design Response Surface Methodology

作　　者：胡月月 聂继红[2] 薛兆坤 刘艺 HU Yueyue;NIE Jihong;XUE Zhaokun;LIU Yi(Urumqi Hospital of Traditional Chinese Medicine,Urumqi 830000,China;Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University,Urumqi 830000,China)

机构地区：[1]乌鲁木齐市中医医院药学部,新疆乌鲁木齐830000 [2]新疆医科大学附属中医医院药学部,新疆乌鲁木齐830000

出　　处：《中国民族民间医药》2023年第16期36-40,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：国家中医药管理局国家中医临床研究基地科研专题项目(JDZX2021237)。

摘　　要：目的:采用星点设计-响应曲面法优选归芪扶正颗粒最佳成型工艺。方法:以成型率、吸湿率、休止角为考察指标,在明确辅料种类后,采用星点设计-响应曲面法优选辅料用量、乙醇浓度等成型工艺参数,并对颗粒的包装湿度进行考察。结果:最佳成型工艺为:浸膏粉∶甘露醇∶炒六神曲=6∶2∶1比例混合,以87%乙醇为粘合剂制粒,包装湿度应控制在65%以下。结论:采用星点设计-响应曲面法选归芪扶正颗粒最佳成型工艺稳定可靠,可为后期生产提供相关依据。Objective Central composite design response surface methodology was used to optimize the molding process of Gui qi fu zheng granules.Methods Taking forming rate,moisture absorption rate and angle of repose as the index,after clarifying the type of excipient,central composite design response surface methodology was used to optimize the molding process parameters such as excipients dosage,ethanol concentration,and the packaging humidity of granule was investigated.Results The optimum molding process was determined as follows:the ratio of extract powder to mannitol to divinity powder was 6∶2∶1,and 87%ethanol was used as binder for granulation,the packaging humidity should be lower than 65%.Conclusion The optimal molding process of Gui qi Fu zheng granules is stable and reliable by using central composite design response surface methodology,which can provide relevant basis for later production.

关 键 词：归芪扶正颗粒 成型工艺 星点设计-响应曲面法 吸湿曲线 

分 类 号：R282.2[医药卫生—中药学]