氯雷他定联合甲基强的松冲击治疗小儿过敏性紫癜的效果观察  

Effect of loratadine combined with methylprednisolone pulse therapy on allergic purpura in children

作　　者：施文洁[1] 宋文涛[1] 胡云芝[1] Shi Wenjie;Song Wentao;Hu Yunzhi(Department of Pediatrics,Jiaozuo People's Hospital,Jiaozuo 454150,China)

机构地区：[1]焦作市人民医院儿科,焦作454150

出　　处：《中国实用医刊》2023年第6期112-115,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨氯雷他定联合甲基强的松冲击治疗小儿过敏性紫癜的临床效果。方法抽取2018年7月至2021年9月焦作市人民医院收治的过敏性紫癜患儿92例,按照随机数字表法分为观察组与对照组,每组46例。对照组采用氯雷他定治疗,观察组在其基础上采用甲基强的松冲击治疗。比较两组疗效、临床症状改善时间、血清炎症因子水平[白细胞介素-8(IL-8)、C反应蛋白(CRP)]、免疫功能水平(T淋巴细胞亚群CD8^(+)、CD4^(+))及不良反应发生率。结果观察组总有效率(95.65%,44/46)高于对照组(80.43%,37/46),P<0.05。观察组关节肿痛、腹痛、皮肤紫癜及水肿改善时间短于对照组(P<0.05);治疗后,观察组IL-8、CRP水平低于对照组(P<0.05);治疗后,观察组CD8^(+)水平低于对照组,CD4^(+)水平高于对照组(P<0.05)。观察组不良反应发生率(4.35%,2/46)与对照组(6.52%,3/46)比较差异未见统计学意义(P>0.05)。结论氯雷他定联合甲基强的松冲击治疗小儿过敏性紫癜可提高疗效,缓解炎症反应,抑制免疫反应,改善临床症状,并存在用药安全性。Objective To investigate the effect of loratadine combined with methylprednisolone pulse therapy in the treatment of allergic purpura in children.Methods A total of 92 children with allergic purpura treated in Jiaozuo People’s Hospital from July 2018 to September 2021 were selected,and they were divided into observation group and control group according to the random number table method,with 46 cases in each group.The control group was treated with loratadine,and the observation group was treated with methylprednisolone pulse therapy based on the treatment of the control group.The curative effect,improvement time of clinical symptom,levels of serum inflammatory factors,including interleukin-8(IL-8)and C-reactive protein(CRP),immune function assessed by T lymphocyte subsets,including cluster of differentiation 8^(+)(CD8^(+))and cluster of differentiation 4^(+)(CD4^(+)),and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group(95.65%,44/46)was higher than that of the control group(80.43%,37/46),P<0.05.The improvement time of joint swelling and pain,abdominal pain,skin purpura and edema in the observation group were shorter than those in the control group(P<0.05).After treatment,the levels of IL-8 and CRP in the observation group were lower than those in the control group(P<0.05).After treatment,the level of CD8^(+)in the observation group was lower than that in the control group,and the level of CD4^(+)in the observation group was higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(4.35%,2/46)and the control group(6.52%,3/46),P>0.05.Conclusions Loratadine combined with methylprednisolone pulse therapy in the treatment of allergic purpura in children can improve the efficacy,relieve inflammation,promote immune function,improve clinical symptoms,and has drug safety.

关 键 词：过敏性紫癜 小儿 氯雷他定 甲基强的松 冲击治疗 

分 类 号：R725.5[医药卫生—儿科]