葛根素注射液联合胺碘酮治疗冠心病PCI术后并发心律失常的效果研究  

Curative effect of puerarin injection combined with amiodarone on arrhythmia after PCI for coronary heart disease

作　　者：解璐 贺凯[2] 关孟梦 Xie Lu;He Kai;Guan Mengmeng(Cardiac Surgical Intensive Care Unit,Zhengzhou Seventh People’s Hospital,Zhengzhou 450000,China;Hemodialysis Room,Zhengzhou Seventh People’s Hospital,Zhengzhou 450000,China;Electrocardiogram Room,Zhengzhou Seventh People’s Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市第七人民医院CSICU,郑州450000 [2]郑州市第七人民医院血液透析室,郑州450000 [3]郑州市第七人民医院心电图室,郑州450000

出　　处：《中国实用医刊》2023年第6期116-119,共4页Chinese Journal of Practical Medicine

摘　　要：目的探究葛根素注射液联合胺碘酮治疗冠心病经皮冠状动脉介入术(PCI)术后并发心律失常的效果。方法抽取2018年11月至2020年11月郑州市第七人民医院收治的冠心病PCI术后并发心律失常患者80例,按随机数字表法分为对照组与观察组,每组40例。对照组采用胺碘酮治疗,观察组在对照组基础上加用葛根素注射液。比较两组治疗效果、中医证候积分、心功能[左室舒张末期内径(LVEDD)、左室射血分数(LVEF)]、血液流变学指标及不良反应发生情况。结果观察组总有效率(95.00%,38/40)高于对照组(77.50%,31/40),P<0.05。治疗后,观察组心悸胸痛及倦怠乏力评分低于对照组(P<0.05);治疗后,观察组LVEDD短于对照组,LVEF高于对照组(P<0.05);治疗后,观察组全血比黏度、血浆黏度均低于对照组(P均<0.05)。观察组不良反应发生率(5.00%,2/40)和对照组(7.50%,3/40)比较差异未见统计学意义(P>0.05)。结论葛根素注射液联合胺碘酮治疗冠心病PCI术后并发心律失常存在理想的疗效,可改善中医证候积分及血液流变学指标,提高心功能,存在用药安全性。Objective To investigate the therapeutic effect of puerarin injection combined with amiodarone on arrhythmia after percutaneous coronary intervention(PCI)for coronary heart disease.Methods Eighty patients who had arrhythmia after PCI for coronary heart disease in Zhengzhou Seventh People’s Hospital from November 2018 to November 2020 were selected,and they were divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with amiodarone,and the observation group was treated with puerarin injection based on the treatment of the control group.The curative effect,traditional Chinese medicine(TCM)syndrome score,cardiac function assessed by left ventricular end-diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF),the hemorheological indexes and adverse reactions were compared between the two groups.Results The total effective rate of the observation group(95.00%,38/40)was higher than that of the control group(77.50%,31/40),P<0.05.After treatment,the palpitations-chest pain score and fatigue score in the observation group were lower than those in the control group(P<0.05).After treatment,the observation group had shorter LVEDD and higher LVEF,compared with the control group(P<0.05).After treatment,the whole blood specific viscosity and plasma viscosity of the observation group were lower than those of the control group(allP<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(5.00%,2/40)and the control group(7.50%,3/40),P>0.05.Conclusions Puerarin injection combined with amiodarone has an ideal effect in the treatment of arrhythmia after PCI for coronary heart disease,which can improve the traditional Chinese medicine syndrome score and hemorheological indexes,improve cardiac function,and has the safety of medication.

关 键 词：冠心病 经皮冠状动脉介入术 心律失常 胺碘酮 葛根素注射液 

分 类 号：R541.4[医药卫生—心血管疾病] R541.7[医药卫生—内科学]