光固化3D打印微针在透皮给药系统中的研究进展  

Research Progress of Photocuring 3D Printing Microneedles in Transdermal Drug Delivery Systems

作　　者：张怡心 楚皓文 李翔 洪晓轩 韩晓璐 王增明 康东周[1] 郑爱萍 Zhang Yixin;Chu Haowen;Li Xiang;Hong Xiaoxuan;Han Xiaolu;Wang Zengming;Kang Dongzhou;Zheng Aiping(School of Pharmacy,YanbianUniversity,Yanji133002,China;Institute of Toricology and Pharmacology,Academy of Military Medical Sciences,Beijing 100850,China;Unit 32268 of the Chinese People's Liberation Army,Dali 671000,China)

机构地区：[1]延边大学药学院,吉林延吉133002 [2]军事医学研究院毒物药物研究所,北京100850 [3]中国人民解放军32268部队,云南大理671000

出　　处：《微纳电子技术》2023年第7期979-987,共9页Micronanoelectronic Technology

基　　金：国家自然科学基金(82073793)。

摘　　要：微针是一种新型的透皮给药方式,因具有无痛、生物利用度高及易给药等特点而被广泛关注。介绍了微针的分类和释药机制、光固化3D打印微针技术的原理和优缺点及其应用,重点分析了光固化3D打印微针在皮肤疾病治疗、胰岛素递送、癌症治疗和美容医疗方面应用的研究进展,阐述了光固化3D打印微针具有可以显著提高药物经皮渗透率、提高给药精确性、减少全身副作用的独特优势。最后,对光固化3D打印微针当前面临的材料生物相容性差、载药量低和现行法规不完善等问题进行探讨,并对其发展前景进行了展望。Due to painless,high bioavailability and easy drug delivery,microneedle is a new transdermal drug delivery method,which has been widely concerned.The classification and drug release mechanism of microneedles,the principle,advantages,disadvantages and application of photocuring 3D printing microneedle technology are introduced.The research progresses of photocuring 3D printing microneedles applied in skin disease treatment,insulin delivery,cancer treatment and aesthetic medicine are emphatically analyzed.The unique advantagesof photocuring 3D printing microneedles are described,which can significantly improve the transdermal permeability of drugs,improve the accuracy of drug delivery and reduce systemic side effects.Finally,the current problems such as poor material biocompatibility,low drug loading and imperfect existing laws and regulations of photocuring 3D printing microneedles are discussed,and their development prospects are forecasted.

关 键 词：微针 光固化3D打印 透皮给药 胰岛素递送 生物相容性 

分 类 号：R944.2[医药卫生—药剂学]