白介素-1家族与痛风关系的研究进展  

Research Progress on the Relationship between Interleukin-1 Family and Gout

作　　者：郜莉娜[1] 谭雨晴 尤崇革[1] GAO Lina;TAN Yuqing;YOU Chongge(Laboratory Medicine Center,Lanzhou University Second Hospital,Lanzhou 730030,China;Lanzhou University Second Clinical Medical School,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院检验医学中心,兰州730030 [2]兰州大学第二临床医学院,兰州730030

出　　处：《中国细胞生物学学报》2023年第6期954-961,共8页Chinese Journal of Cell Biology

基　　金：甘肃省重点研发计划(批准号:21YF5FA126);甘肃省高等学校创新基金(批准号:2021B-037);兰州大学第二医院萃英科技创新项目(批准号:CY2020-BJ05);兰州大学第二医院萃英学子科研培育计划(批准号:CYXZ2021-44)资助的课题。

摘　　要：白介素-1(interleukin-1,IL-1)家族共有11个成员,它们分别作为促炎细胞因子或抗炎细胞因子参与体内炎症反应过程。痛风最典型的表现是关节炎,IL-1β是引起痛风性关节炎发作的核心细胞因子,然而近年来的研究发现IL-1家族其他成员也与痛风密切相关。IL-1家族成员不仅在痛风性炎症起始阶段起重要作用,还参与了炎症持续及器官损伤过程,IL-1也是痛风患者炎症程度的判断指标和痛风治疗的潜在靶点。该文就IL-1家族细胞因子与痛风的关系进行综述,旨在全面阐述IL-1家族与痛风的关系,并为痛风防治提供依据。IL-1(interleukin-1)family has 11 members,and they participate in inflammatory processes as proinflammatory or anti-inflammatory cytokines.The most typical manifestation of gout is arthritis,and IL-1βis the core cytokine that causes gouty arthritis.However,recent studies have found that other members of the IL-1 family are also closely related to gout.IL-1 family not only play an important role in the initial stage of gout inflammation,but also participate in the inflammation persist and organ damage.IL-1 is also a judgment indicator of gout inflammation and a potential new target for gout treatment.This article reviews the relationship between IL-1 family cytokines and gout,in order to fully understand the relationship between IL-1 family and gout,and provide a basis for the prevention and treatment of gout.

关 键 词：痛风 白介素-1 促炎 抗炎 

分 类 号：R589.7[医药卫生—内分泌]