Novel biomonitoring method for determining five classes of legacy and alternative flame retardants in human serum samples  

作　　者：Xiaolin Guan Gaoxin Zhang Lingling Meng Mei Liu Liyuan Zhang Chuxuan Zhao Yingming Li Qinghua Zhang Guibin Jiang 

机构地区：[1]Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education,Key Laboratory of Polymer Materials Ministry of Gansu Province,College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070,China [2]State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China [3]Department of Endocrinology and Metabology,The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Jinan 250014,China [4]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Journal of Environmental Sciences》2023年第9期111-122,共12页环境科学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22193052,22076215 and 21965032);the Eco-Environmental Excellent Innovation Projects of the Research Center for Eco-Environmental Sciences(No.RCEES-EEI-2019-01);the Special Project of EcoEnvironmental Technology for Peak Carbon Dioxide Emissions and Carbon Neutrality,Chinese Academy of Sciences(No.RCEES-TDZ-2021-23).

摘　　要：Flame retardants(FRs)are ubiquitous in environment and biota and may pose harm to human health.In recent years,concern regarding legacy and alternative FRs has been intensified due to their widespread production and increasing contamination in environmental and human matrices.In this study,we developed and validated a novel analytical method for simultaneous determination of legacy and alternative FRs,including polychlorinated naphthalenes(PCNs),short-and middle-chain chlorinated paraffins(SCCPs and MCCPs),novel brominated flame retardants(NBFRs),and organophosphate esters(OPEs)in human serum.Serum samples were prepared by liquid-liquid extraction using ethyl acetate,and purified with Oasis®HLB cartridge and Florisil–silica gel columns.Instrumental analyses were carried out using gas chromatography-triple quadrupole mass spectrometry,highresolution gas chromatography coupled with high-resolution mass spectrometry,and gas chromatography coupled with quadrupole time-of-flight mass spectrometry,respectively.The proposed method was validated for linearity,sensitivity,precision,accuracy,and matrix effects.Method detection limits for NBFRs,OPEs,PCNs,SCCPs,and MCCPs were 4.6×10^(–4)–8.6×10^(–2),4.3×10^(–3)–1.3,1.1×10^(–5)–1.0×10^(–4),1.5,and 9.0×10–1 ng/mL,respectively.Matrix spike recoveries ranged from 73%–122%,71%–124%,75%–129%,92%–126%,and 94%–126%for NBFRs,OPEs,PCNs,SCCPs,and MCCPs,respectively.The analytical method was applied for detection of real human serum.CPs were the dominant FRs in serum,indicating CPs were widely presented in human serum and should be pay more attention for their health risk.

关 键 词：Human serum BIOMONITORING Novel brominated flame retardants Organophosphate esters Chlorinated paraffins Polychlorinated naphthalenes 

分 类 号：X838[环境科学与工程—环境工程]