甲状腺功能亢进症合并脑静脉窦血栓一例并文献复习  

Hyperthyroidism and cerebral venous sinus thrombosis:One case report and literature review

作　　者：潘润洲 王晗 赵永才[1] Pan Runzhou;Wang Han;Zhao Yongcai(Fourth Department of Endocrinology,Cangzhou Central Hospital,Cangzhou 061000,China;Department of Nuclear Magnetic Resonance,Cangzhou Central Hospital,Cangzhou 061000,China)

机构地区：[1]沧州市中心医院内分泌四科,沧州061000 [2]沧州市中心医院磁共振成像科,沧州061000

出　　处：《中华内分泌代谢杂志》2023年第6期517-521,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：本文报道1例甲状腺功能亢进症(甲亢)合并脑静脉窦血栓(cerebral venous sinus thrombosis,CVST)病例。患者女性33岁,因甲亢入内分泌科,次日凌晨出现肢体抽搐、意识不清,"癫痫样"发作,转入神经内科。患者临床表现及实验室检查提示甲亢、毒性弥漫性甲状腺肿(Graves病)合并CVST形成、颈内静脉血栓形成、静脉性急性脑梗死。在治疗甲亢同时予以规范抗凝、降颅压治疗,患者病情好转。随访3个月,患者预后良好。截至目前,国内外已有多篇个案报道共描述了41例甲亢合并CVST患者。对于甲亢合并头痛、尤其是合并癫痫或偏瘫等严重神经症状的患者,临床医师需提高警惕,及时完善影像学检查评估CVST可能。CVST明确诊断后,应在治疗甲亢的同时积极治疗CVST,以期取得良好的预后。This article reports a case of hyperthyroidism complicated with cerebral venous sinus thrombosis(CVST).A 33-year-old woman patient was admitted to the Department of Endocrinology due to hyperthyroidism.She developed convulsions of the legs,unconsciousness,and"epileptic"seizures in the early morning of the next day and was transferred to the Department of Neurology.The patient′s clinical manifestations and laboratory tests suggested hyperthyroidism,Graves′disease complicated with CVST formation,internal jugular vein thrombosis,and venous acute cerebral infarction.After standard treatment for hyperthyroidism,anticoagulation,and reduction in intracranial pressure were given,the patient′s condition improved.After 3 months of follow-up,the patient had a good prognosis.Until now,41 patients with hyperthyroidism complicated with CVST have been described in case reports.For patients with hyperthyroidism presenting with headaches,especially those with severe neurological symptoms such as epilepsy or hemiplegia,clinicians should be vigilant and conduct appropriate imaging evaluations to assess the possibility of CVST.Once the diagnosis of CVST is confirmed,treatment for both hyperthyroidism and CVST should be initiated simultaneously to achieve a favorable prognosis.

关 键 词：甲状腺功能亢进症 脑静脉窦血栓 

分 类 号：R581.1[医药卫生—内分泌] R743[医药卫生—内科学]