糖尿病血管重构作用机制的研究进展  

Mechanism of Vascular Remodeling Action in Diabetes Mellitus

作　　者：薛佳欣 宫天宇 梁馨芳 王帆[1] 张晓卉[1] XUE Jiaxin;GONG Tianyu;LIANG Xinfang;WANG Fan;ZHANG Xiaohui(Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China;The First Affiliated Hospital of Jiamusi University,Jiamusi 154002,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学附属第一医院心血管内科,黑龙江哈尔滨150001 [2]佳木斯大学附属第一医院,黑龙江佳木斯154002

出　　处：《心血管病学进展》2023年第8期738-742,共5页Advances in Cardiovascular Diseases

基　　金：黑龙江省博士后科研启动金(LBHQ18080);黑龙江省自然科学基金(LH2020H034);哈尔滨医科大学附属第一医院院基金(2019M08);哈尔滨医科大学附属第一医院院杰出青年基金(HYD2020JQ0005)。

摘　　要：糖尿病(DM)是以血葡萄糖水平慢性升高为特征的代谢性疾病,血糖长期控制不佳引发的血管并发症会严重影响预后和患者的生活质量。血管重构是一个动态变化的过程,从一开始的适应性变化进一步发展成为DM血管并发症的病理基础。及时有效地药物干预逆转血管重构将在很大程度上避免DM血管并发症的发生。阐明DM血管重构的作用机制具有重大临床意义,现就DM血管重构涉及的相关机制做一综述,为今后靶向药物筛选和DM血管并发症防治提供新思路。Diabetes mellitus(DM)is a metabolic disease characterized by a chronic increase in blood glucose levels,and vascular complications arising from poor long-term glucose control can seriously affect the prognosis and the quality of life of patients.Vascular remodeling is a dynamic change process that can further develop from the initial adaptive changes into the pathological basis of vascular complications in DM.Timely and effective pharmacological intervention to reverse vascular remodeling will largely avoid the occurrence of vascular complications in DM.It is of great clinical significance to elucidate the mechanisms involved in DM vascular remodeling,and this article reviews the relevant mechanisms involved in DM vascular remodeling to provide new ideas for future targeted drug screening and prevention of DM vascular complications.

关 键 词：糖尿病 血管重构 平滑肌细胞表型转化 

分 类 号：R587.1[医药卫生—内分泌]