m6A甲基化修饰在前列腺癌发生发展中的调控机制  

Regulation Mechanism of m6A Methylation Modification in the Development of Prostate Cancer

作　　者：张乐 王振 张钰哲 ZHANG Le;WANG Zhen;ZHANG Yu-Zhe(College of Basic Medicine Science(Pathology and Pathophysiology),Dali University,Dali 671003,Yunnan,China;Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan,Dali 671003,Yunnan,China)

机构地区：[1]大理大学基础医学院(病理学与病理生理学),云南大理671003 [2]云南省滇西抗病原植物资源筛选研究重点实验室,云南大理671003

出　　处：《中国生物化学与分子生物学报》2023年第8期1047-1058,共12页Chinese Journal of Biochemistry and Molecular Biology

基　　金：云南省科技厅项目(No.2019FH001(-032));云南省滇西抗病原植物资源筛选研究重点实验室开放项目(No.APKL2101);大理大学博士科研启动基金项目(No.KYBS2018012)资助。

摘　　要：N6-腺苷甲基化(N6-adenosine methylation)是腺苷N6位点的甲基化形式,常出现在真核生物的mRNA中,是最常见的RNA内部修饰的方式之一。研究表明,m6A通过调节基因的表达来影响细胞的生物过程;同时m6A的调控因子也在各种癌症的发生、发展中发挥着关键作用。前列腺癌(prostate cancer,PCa)是一种常见的男性恶性肿瘤,超过60岁的男性的患病风险逐年攀升,并且随着人口老龄化的问题,可以预计PCa的患病数目会继续升高。近年来,关于m6A在肿瘤发生发展中的作用逐渐受到广泛关注,但是m6A甲基化修饰在PCa中的研究仍然有限,因此,进一步探讨二者之间的关系显得尤为重要。本文综述了近年来关于m6A甲基化修饰在PCa中的作用、机制及应用的研究进展,尤其详细综述了METTL3,FTO,YTHDF2三种经典的m6A相关调控蛋白质在PCa中的作用机制;并阐述了m6A在晚期PCa(例如:去势抵抗性前列腺癌,骨转移性前列腺癌)中的潜在应用。从甲基化修饰角度为PCa的早期诊断、治疗和预后挖掘一套有效治疗策略,为实现个体化治疗提供更多理论参考。N6-adenosine methylation,a form of methylation of the adenosine N6 site,is often found in eukaryotic mRNA and is one of the most common forms of internal RNA modification.Studies have shown that m6A affects cellular biological processes by regulating gene expression;also the regulators of m6A play a key role in the occurrence and development of various cancers.Prostate Cancer(PCa)is a common malignant tumor in men,and the risk of the disease in men over 60 years of age is increasing year by year.With the aging population,the number of PCa can be expected to continue to rise.In recent years,the role of m6A in tumorigenesis has received widespread attention,but studies on m6A methylation modification in PCa are still limited;therefore,it is particularly important to further explore the relationship between m6A methylation and PCa.In this paper,we review the recent research progress on the role,mechanism,and application of m6A methylation modification in PCa,especially the detailed review of the mechanism of METTL3,FTO,YTHDF2,three classical m6A-related regulatory proteins in PCa;and the potential application of m6A in advanced PCa(e.g.,destructive resistant prostate cancer,bone me-tastatic prostate cancer).From the perspective of methylation modification,this paper may provide some clues to find effective therapeutic strategies for early diagnosis,treatment,and prognosis of PCa,and more theoretical references to achieve individualized treatment.

关 键 词：N6-腺苷甲基化 前列腺癌 去势抵抗性前列腺癌 骨转移性前列腺癌 免疫治疗 

分 类 号：R934[医药卫生—生药学]