呼吸道病毒抗原、抗体检测及二者联合检测在呼吸道感染老年患者中的临床应用价值  

Clinical value of detection of respiratory virus antigen and antibody and their combined detection in elderly patients with respiratory tract infection

作　　者：武志芳[1] 张刚强[1] 韩春滔 Wu Zhi-fang;Zhang Gang-qiang;Han Chun-tao(Clinical Laboratory,Anyang Hospital of Traditional Chinese Medicine,Anyang 455000,Henan,China)

机构地区：[1]安阳市中医院检验科,河南安阳455000

出　　处：《四川生理科学杂志》2023年第9期1604-1607,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨呼吸道病毒抗原、抗体检测及二者联合检测在呼吸道感染老年患者中的临床应用价值。方法:我院2019年11月至2021年11月期间收治的85例高危呼吸道感染老年患者,所有患者均接受呼吸道病毒抗原、抗体检测。呼吸道病毒培养结果作为金标准,分析呼吸道病毒抗原和抗体检测对呼吸道病毒的检出率、两种方式单独和联合检测与病理结果诊断的一致性以及对呼吸道病毒的诊断效能。结果:呼吸道病毒抗体检测对呼吸道病毒诊断价值与金标准一致性尚可(kappa=0.401),特异度、灵敏度、阳性预测值、阴性预测值、诊断准确率分为44.44%(8/18)、83.58%(56/67)、84.84%(56/66)、42.11%(8/19)、75.29%(64/85)。呼吸道病毒抗原检测对呼吸道病毒诊断价值与金标准一致性尚可(kappa=0.482),特异度、灵敏度、阳性预测值、阴性预测值、诊断准确率分为61.11%(11/18)、88.06%(59/67)、89.39%(59/66)、57.89%(11/19)、82.35%(70/85)。联合检测对呼吸道病毒诊断价值与金标准一致性好(kappa=0.828),特异度、灵敏度、阳性预测值、阴性预测值、诊断准确率分为88.89%(16/18)、97.01%(65/67)、95.58%(65/68)、94.11%(16/17)、94.11%(80/85)。联合检测在诊断特异度、准确度、阴性预测值、诊断准确率高于呼吸道病毒抗原检测与呼吸道病毒抗体检测(P<0.05),联合检测的曲线下面积为0.821,其敏感度为91.30%,特异度为89.62%,联合检测相比较单独检测有统计学意义(P<0.05)。结论:呼吸道病毒抗原、抗体检测均可对呼吸道感染进行检出,且联合检测诊断价值更高。Objective:To investigate the clinical application value of detection of respiratory virus antigen,antibody and their combined detection in elderly patients with respiratory tract infection.Methods:85 elderly patients with high-risk respiratory tract infection were admitted to our hospital from November 2019 to November 2021.All patients were tested for respiratory virus antigen and antibody.The results of respiratory virus culture were used as thegold standard to analyze the detection rate of respiratory virus antigen and antibody detection,the consistency between the two methods of single and combined detection and pathological diagnosis,and the diagnostic efficacy of respiratory virus.Results:The diagnostic value of respiratory virus antibody was in good agreement with the gold standard(kappa=0.401).Specificity,sensitivity,positive predictive value,negative predictive value and diagnostic accuracy were 44.44%(8/18),83.58%(56/67),84.84%(56/66),42.11%(8/19),75.29%(64/85).The diagnostic value of respiratory virus antigen was consistent with the gold standard(kappa=0.482).Specificity,sensitivity,positive predictive value,negative predictive value and diagnostic accuracy were divided into 61.11%(11/18),88.06%(59/67),89.39%(59/66),57.89%(11/19),82.35%(70/85).The diagnostic value of combined test was in good agreement with the gold standard(kappa=0.828).Specificity,sensitivity,positive predictive value,negative predictive value and diagnostic accuracy were 88.89%(16/18),97.01%(65/67),95.58%(65/68),94.11%(16/17),94.11%(80/85).The diagnostic specificity,accuracy,negative predictive value and diagnostic accuracy of combined detection were higher than those of respiratory virus antigen detection and respiratory virus antibody detection(P<0.05),the area under the curve of combined test was 0.821.the sensitivity and specificity were 91.30%and 89.62%,respectively.The combined detection had statistical significance compared with the single detection(P<0.05).Conclusion:The detection of respiratory virus antigen and antibody ca

关 键 词：呼吸道病毒 抗原 抗体 呼吸道感染 

分 类 号：R56[医药卫生—呼吸系统]