超声、磁共振及染色体基因检测联合诊断胎儿颅脑异常的临床价值  

Roles of ultrasound,MRI and chromosomal gene detection in the diagnosis of fetal brain abnormalities

作　　者：张国梁 王利顺 李伟伟 华天书 王启臣 赵瑶瑶 ZHANG Guoliang;WANG Lishun;LI Weiwei;HUA Tianshu;WANG Qichen;ZHAO Yaoyao(Department of Radiology,Maternal and Child Care Center of Qinhuangdao,Qinhuangdao 066000,China)

机构地区：[1]秦皇岛市妇幼保健院放射科,河北秦皇岛066000

出　　处：《中国医学物理学杂志》2023年第8期985-987,共3页Chinese Journal of Medical Physics

基　　金：河北省医学科学研究项目(20191390)。

摘　　要：目的:探讨超声(US)、磁共振(MRI)及染色体基因检测联合诊断胎儿颅脑异常的临床价值。方法:回顾性分析影像检查提示胎儿颅内可能存在异常的孕妇120例作为研究对象。通过对胎儿染色体微阵列分析(CMA)及颅脑US、MRI检查比较,对MRI与US的诊断结果符合率进行分析。结果:MRI与US诊断结果符合率差异无统计学意义(P>0.05)。US、MRI及CMA联合诊断结果中,特异性90.83%,灵敏性90.00%,假阳性10.83%,假阴性10.00%。结论:US、MRI可有效诊断胎儿颅内发育异常情况;MRI较US对透明隔间腔检查占优;有指征的孕妇应该进行US、MRI及CMA联合诊断。Objective To explore the clinical value of the combination of ultrasound(US),magnetic resonance imaging(MRI)and chromosomal gene detection in the diagnosis of fetal brain abnormalities.Methods A retrospective analysis was carried out on 120 pregnant women with imaging findings suggesting possible brain abnormalities in the fetuses.The diagnosis rates of MRI and US were analyzed by comparing fetal chromosome microarray analysis(CMA)with brain US and MRI.Results There was no significant difference between MRI and US in diagnosis rate(P>0.05).The combination of US,MRI and CMA had a specificity of 90.83%,sensitivity of 90.00%,false positive rate of 10.83%and false negative rate of 10.00%for the diagnosis of fetal brain abnormalities.Conclusion Both US and MRI can effectively diagnose fetal brain abnormalities,but MRI is superior over US in the detection of cavity of septum pellucidum.US,MRI and CMA should be combined for pregnant women with the corresponding indications.

关 键 词：胎儿发育异常 超声 磁共振 染色体基因检测 联合诊断 

分 类 号：R714.2[医药卫生—妇产科学]