分析左氧氟沙星治疗结核病的效果  

Analysis of the Effect of Levofloxacin in the Treatment of Tuberculosis

作　　者：黄小丽 HUANG Xiaoli(Department of Pharmacy,the First People's Hospital of Dingnan County,Ganzhou 341900,China)

机构地区：[1]江西省赣州市定南县第一人民医院药房,江西赣州341900

出　　处：《中国医药指南》2023年第24期37-40,共4页Guide of China Medicine

摘　　要：目的观察左氧氟沙星应用于结核病患者治疗当中所发挥的治疗作用。方法在2019年1月至2019年12月到我院治疗的结核病患者中选出88例以随机方法分为观察组和对照组,每组各44例。对照组通过常规的抗结核治疗方案实施治疗,观察组则通过含左氧氟沙星的治疗方案对患者实施治疗,对经过不同治疗后两组患者的治疗有效率、ADR发生率、痰菌转阴率、MDR-TB发生率、治疗不同时间段的血药浓度、治疗前后的免疫功能、肝功能等进行统计学分析和比较。结果①观察组(42例,占95.45%)相比对照组(35例,占79.55%)具有更高的治疗有效率水平值,数据差异有统计学意义(P<0.05)。②观察组(6例,占13.64%)相比对照组(4例,占9.09%)在ADR发生率方面没有明显的统计学差异性(P>0.05)。③观察组具备更为理想的痰菌转阴率,且MDR-TB发生率更低,数据差异有统计学意义(P<0.05)。④治疗3 d后,两组患者的血药浓度无显著性差异(P>0.05),但治疗5 d后和1周后,观察组的血药浓度明显高于对照组,数据差异有统计学意义(P<0.05)。⑤治疗前,两组患者的CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)、Treg没有明显的统计学差异性(P>0.05),治疗后,两组患者的上述免疫功能指标均有改进,但观察组的改善效果更显著,数据差异有统计学意义(P<0.05)。⑥两组患者在治疗前ALB、AST、ALT等差异不显著(P>0.05),治疗后,观察组比对照组改善更好,数据差异有统计学意义(P<0.05)。结论将左氧氟沙星应用在结核病患者的治疗中可以有效提升患者的临床治疗疗效,安全性较高,可以促进痰菌转阴,能够有效提高用药后的需要浓度,更好的改善患者的免疫功能和肝功能,有值得推荐的价值。Objective To study the therapeutic effect of levofloxacin in the treatment of tuberculosis patients.Methods A total of 88 tuberculosis patients who were treated in our hospital from January 2019 to December 2019 were selected and randomly divided into an observation group and a control group,with an average of 44 cases.The control group was treated with conventional anti-tuberculosis treatment plan,while the observation group was treated with levofloxacin-containing treatment plan.,MDR-TB incidence,blood drug concentration in different time periods of treatment,immune function before and after treatment,liver function,etc.were statistically analyzed and compared.Results(1)The observation group(42 cases,accounting for 95.45%)had a higher level of therapeutic efficacy than the control group(35 cases,accounting for 79.55%),and the data difference met the statistical standard(P<0.05).(2)There was no significant difference in the incidence of adverse drug reactions in the observation group(6 cases,accounting for 13.64%)compared with the control group(4 cases,accounting for 9.09%)(P>0.05).(3)The observation group had more the ideal negative rate of sputum bacteria,and the incidence of MDR-TB is lower,and the data difference meets the statistical standard(P<0.05).(4)After 3 days of treatment,there was no significant difference in blood drug concentration between the two groups(P>0.05),but after 5 days and 1 week of treatment,the blood drug concentration in the observation group was significantly higher than that in the control group,and the data difference met the statistical standard(P<0.05).(5)Before treatment,the CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+)and Treg there was no significant statistical difference between the two groups(P>0.05).After treatment,the above immune function indexes of the two groups were improved,but the improvement effect of the observation group was more significant,and the data difference met the statistical standard(P<0.05).(6)There was no significant difference in ALB,AST,ALT between th

关 键 词：结核病 左氧氟沙星 免疫功能 肝功能 血药浓度 痰菌 

分 类 号：R521[医药卫生—内科学]