脓毒症患者血脂水平变化及其与患者炎症程度、病情评分的相关性分析  

Changes in Lipid Levels in Patients with Sepsis and Their Correlation with the Degree of Inflammation and Condition Score of the Patients

作　　者：刘俊贤 瞿嵘[2] LIU Junxian;QU Rong(Shantou University Medical College,Shantou 515000,China;Intensive Care Medicine,Huizhou Central People's Hospital,Huizhou 516001,China)

机构地区：[1]汕头大学医学院,广东汕头515000 [2]惠州市中心人民医院重症医学科,广东惠州516001

出　　处：《中国医药指南》2023年第24期83-85,共3页Guide of China Medicine

摘　　要：目的研究脓毒症患者血脂水平变化及其与炎症程度、病情评分的相关性。方法行回顾性研究并选惠州市中心人民医院重症监护室的115例脓毒症患者为观察组,以同期非脓毒症患者100例为对照组。两组患者均行血脂指标、炎症指标检测,以及序贯器官衰竭评分和急性生理学与慢性健康状况评分Ⅱ评分评估。分析脓毒症患者血脂指标与炎性因子、病情评分之间的相关性。结果观察组的TC、HDL-C、LDL-C水平低于对照组,TG水平高于对照组;观察组的IL-6、CRP、SAA、PCT水平高于对照组;观察组的SOFA、APACHEⅡ评分高于对照组,差异有统计学意义(P<0.05);脓毒症患者的TC、HDL-C、LDL-C与IL-6、SAA、PCT均呈负相关性(P<0.05),同时脓毒症患者的HDL-C、LDL-C与SOFA、APACHEⅡ评分均呈负相关性(P<0.05)。结论脓毒症患者的HDL-C、LDL-C均明显下降且与其炎症发展程度和病情严重程度之间呈负相关性,尤其以HDL-C与患者炎症发展程度和病情严重程度之间的相关性最高。Objective To study the changes in lipid levels in sepsis patients and their correlation with the degree of inflammation and condition score.Methods The retrospective study method was used to select 115 patients with sepsis who were admitted to the intensive care unit of Huizhou Central People's Hospital as the observation group,and 100 patients with non sepsis as the control group at the same time.Patients in the 2 groups underwent testing of lipid indices and inflammatory indices,as well as assessment of sequential organ failure score and acute physiology and chronic health status scoreⅡscore.Correlations between lipid indices and inflammatory factors and condition scores were analyzed in patients with sepsis.Result The levels of TC,HDL-C,and LDL-C in the observation group were lower than those in the control group,while the levels of TG were higher than those in the control group;The levels of IL-6,CRP,SAA,and PCT in the observation group were higher than those in the control group;The SOFA and APACHEⅡscores of the observation group were higher than those of the control group,the difference was statistically significant(P<0.05);TC,HDL-C,LDL-C and IL-6,SAA,and PCT were negatively correlated in patients with sepsis(P<0.05),at the same time,the HDL-C and LDL-C scores of patients with sepsis were negatively correlated with SOFA and APACHEⅡscores(P<0.05).Conclusion In patients with sepsis,HDL-C and LDL-C were significantly decreased and negatively correlated with the degree of inflammation and severity of the disease,with the highest correlation between HDL-C and the degree of inflammation and severity of the disease.

关 键 词：脓毒症 血脂水平 炎性因子 病情评分 相关性 

分 类 号：R631[医药卫生—外科学]