2004-2021年雅安市报告15岁及以上艾滋病病毒感染者及病人死亡病例分析  

Analysis of HIV infection and death cases of 15 years old and above in Yaan City from 2004 to 2021

作　　者：岳潇[1] 陈云霞[1] 刘清霞[1] 梁莉[2] YUE Xiao;CHEN Yunxia;LIU Qingxia;LIANG Li(Yaan Center for Disease Control and Prevention,Yaan 625000,Sichuan Province,China;Sichuan Center for Disease Control and Prevention,Chengdu 610041,Sichuan Province,China)

机构地区：[1]雅安市疾病预防控制中心,四川雅安625000 [2]四川省疾病预防控制中心,成都610041

出　　处：《预防医学情报杂志》2023年第8期906-912,共7页Journal of Preventive Medicine Information

摘　　要：目的 分析雅安市艾滋病病毒感染者及病人(以下简称“HIV/AIDS”)死亡病例特征,发现导致死亡的相关因素,为艾滋病防治策略的制定提供支撑依据。方法 从艾滋病防治基本信息系统下载2021年历史卡片,筛选自2004-2021年雅安市15岁及以上HIV/AIDS死亡病例,描述其死亡特点及死亡比例随时间变化趋势,并采用Cox比例风险模型分析死亡的相关危险因素,以P<0.05为差异有统计学意义。结果 截至2021年12月31日,雅安市累计报告15岁及以上HIV/AIDS死亡病例737例。死亡患者的平均确证年龄段为(53.92±18.00)岁,死亡时平均年龄段为(55.80±17.67)岁。死亡时病程阶段为HIV占65.81%(485/737);男性占80.87%(596/737);小学文化程度占44.10%(325/737);医疗机构就诊者检测发现占75.58%(557/737);未接受抗病毒治疗占52.24%(385/737);确诊后1年内未接受CD4^(+)T检测占63.09%(465/737);CD4^(+)T细胞计数小于200个/ul占44.09%(205/465)。主要死因分类中艾滋病无关死亡占69.15%(446/645);2004-2021年,死亡比例从25.00%下降到3.12%,死亡病例的平均存活时长从1.00月延长到36.40月。Cox比例回归模型分析结果显示,死亡风险的危险因素包括AIDS(HR=5.28)、男性(HR=1.64)、医疗机构检测发现(HR=1.91)、确证年龄在50岁以上(HR=1.77);死亡风险的保护因素包括初中及以上文化水平(HR=0.73)、首次CD4检测值在200以上(HR=0.07)、抗病毒治疗(HR=0.06)。结论 雅安市艾滋病患者死亡数逐年上升,死亡比例逐年下降,应继续实施早检测、早发现、早治疗策略,规范管理,提升抗病毒治疗效果,降低死亡比例。Objective To analyze the characteristics of the death cases of HIV infected people and patients(hereinafter referred to as"HIV/AIDS",human immunodeficiency virus/acquired immune deficiency syndrome)in Yaan City,to find out the related factors leading to the death,and to provide support for the formulation of HIV/AIDS prevention and control strategy.Methods The historical cards in 2021 wered ownloaded from the Basic Information System of HIV/AIDS Prevention and Control,and the HIV/AIDS S deaths aged 15 years and above in Ya'an City from 2004 to 2021 were screened.The characteristics of death and the trend of death ratio over time were described,and the Cox proportional risk model was used to analyze the related risk factors of death.P<0.05 was considered statistically significant.Results As of December 31,2021,a total of 737 HIV/AIDS deaths aged 15 years and above had been reported in Yaan City.The mean confirmed age of death cases was(53.92±18.00)years,and the mean age at the time of death was(55.80±17.67)years.At the time of death,65.81%(485/737)were HIV.Males accounted for 80.87%(596/737);44.10%(325/737)were educated in primary school;75.58%(557/737)were found in medical institutions;52.24%(385/737)did not receive antiviral therapy;63.09%(465/737)did not receive CD4^(+)T cell detection within one year after diagnosis;44.09%(205/465)had CD4^(+)T cell count less than 200/ul;69.15%(446/645)of the main causess of death were unrelated to AIDS.From 2004 to 2021,the proportion of deaths decreased from 25.00%to 3.12%,and the average survival time of death cases increased from 1 month to 36.40 months.The results of Cox proportional regression model showed that the risk factors of death included AIDS(hazard ratio HR=5.28),male(HR=1.64),medical institution detection(HR=1.91)and confirmed age above 50 years(HR=1.77).Protective factors for the risk of death included junior high school education or higher(HR=0.73),first CD4^(+)T cell count above 200(HR=0.07),and antiviral therapy(HR=0.06).Conclusions The number of deaths o

关 键 词：HIV/AIDS 死亡病例特征 风险因素 

分 类 号：R512.91[医药卫生—内科学]