艾司氯胺酮泵注对老年全麻患者术中循环影响的临床观察  

Clinical observation of intraoperative infusion of Spravato on improving circulation in elderly patients undergoing general anesthesia

作　　者：刘帅 LIU Shuai(Department of Anesthesia,Haijiya Hospital,Shan County,Shandong Province,Heze 274300,Shandong,China)

机构地区：[1]山东省单县海吉亚医院麻醉科,山东菏泽274300

出　　处：《外科研究与新技术》2023年第2期118-121,共4页Surgical Research and New Technique

摘　　要：目的观察艾司氯胺酮泵注对老年全麻患者术中循环稳定的影响。方法选取2021年5月—2022年10月接受全麻手术治疗的老年患者83例,按随机数字表法将其分为试验组41例及常规组42例。常规组实施常规靶控静脉全麻处理,并选择生理盐水开展目标导向液体治疗。试验组全麻处理同常规组,增用艾司氯胺酮术中泵注实现目标导向液体治疗。分析两组麻醉诱导前(T1)、气管插管前(T2)、插管后1 min(T3)以及插管后10 min(T4)时间点平均动脉压(MAP)以及心率(HR),术后疼痛、镇静,不良反应等差异。结果试验组T2、T3、T4时的MAP分别相较于常规组显著降低;上述时间点试验组HR分别相较于常规组显著降低(均P<0.05)。试验组术后1、2、6h时的VAS评分分别相较于常规组显著降低(均P<0.05)。试验组术后1、2h时的Ramsay评分分别相较于常规组显著升高(均P<0.05)。在不良反应总发生率方面对比,试验组显著低于常规组(均P<0.05)。结论艾司氯胺酮泵注可有效维持老年全麻患者术中循环稳定,提高镇痛以及镇静高效果,降低不良反应发生风险。Objective To observe the influence of intraoperative infusion of Spravato on improving circulation stability in elderly patients under general anesthesia.Methods A total of 83 elderly patients who received general anesthesia surgery from May 2021 to October 2022 were selected,and were divided into an experimental group of 41 cases and a conventional group of 42 cases by random number table method.The conventional group received routine target-controlled intravenous general anesthesia and selected normal saline for goal-directed fluid therapy.The experimental group received general anesthesia treatment as the conventional group,and selected intraoperative infusion of Spravato for goal-directed fluid therapy.The mean arterial pressure(MAP)and heart rate(HR)before anesthesia induction(T1),before endotracheal intubation(T2),1 min after intubation(T3),and 10 min after intubation(T4),as well as postoperative pain,sedation,and adverse reactions were compared between the two groups.Results The MAP and HR at T2,T3,and T4 of the experimental group compared with the conventional group were significantly lower(all P<0.05).The VAS scores at 1 h,2 h,and 6 h after operation in the experimental group were significantly lower than those in the conventional group(all P<0.05).The Ramsay scores at 1 h and 2 h after operation in the experimental group were significantly higher than those in the conventional group(all P<0.05).The total incidence of adverse reactions in the experimental group was significantly lower than that in the conventional group(all P<0.05).Conclusion Intraoperative infusion of Spravato can effectively maintain the stability of circulation in elderly patients under general anesthesia,improve the effect of analgesia and sedation,and reduce the risk of adverse reactions.

关 键 词：全麻 老年 艾司氯胺酮 术中泵注 循环稳定 

分 类 号：R614[医药卫生—麻醉学]