异甘草酸镁注射液致高血压、低钾血症发生情况及影响因素分析  

Incidence and influencing factors of hypertension and hypokalemia caused by magnesium isoglycyrrhizinate injection

作　　者：王娜[1] 张抗怀[1] Na WANG;Kang-Huai ZHANG(Department of Pharmacy,The Second Affiliated Hospital,Xi’an Jiaotong University,Xi’an 710004,China)

机构地区：[1]西安交通大学第二附属医院药学部,西安710004

出　　处：《药物流行病学杂志》2023年第6期626-632,共7页Chinese Journal of Pharmacoepidemiology

摘　　要：目的分析异甘草酸镁注射液致高血压、低钾血症的发生情况及影响因素,为临床安全用药提供参考。方法回顾性分析西安交通大学第二附属医院2022年1月—6月使用异甘草酸镁注射液治疗的住院患者临床资料,记录异甘草酸镁注射液致高血压、低钾血症的发生率及相关特征,并进行影响因素分析。结果300例患者中发生高血压41例,发生率为13.67%,多因素Logistic回归分析结果显示,年龄越大[OR=1.028,95%CI(1.001,1.058),P=0.049]、体重指数越高[OR=1.435,95%CI(1.226,1.681),P<0.001]和用药疗程越长[OR=1.304,95%CI(1.158,1.467),P<0.001]的患者,使用异甘草酸镁注射液时发生高血压的可能性越大。发生低钾血症29例,发生率为9.67%,多因素Logistic回归分析结果显示,年龄越大[OR=1.037,95%CI(1.003,1.072),P=0.033]、用药日剂量越高[OR=1.024,95%CI(1.005,1.043),P=0.011]和用药疗程越长[OR=1.097,95%CI(1.004,1.198),P=0.040]的患者,使用异甘草酸镁注射液时发生低钾血症的可能性越大。结论临床使用异甘草酸镁注射液治疗的过程中应定期监测患者的血压及电解质水平,年龄越大、体重指数越高、用药疗程越长的患者,使用异甘草酸镁注射液时发生高血压的可能性越大。年龄越大、用药日剂量越高、用药疗程越长的患者,使用异甘草酸镁注射液时发生低钾血症的可能性越大。Objective To analyze the occurrence and influencing factors of hypertension and hypokalemia caused by magnesium isoglycyrrhizinate injection,and to provide reference for clinical safe medication.Methods The medical records of inpatients received magnesium isoglycyrrhizinate injection therapy in The Second Affiliated Hospital,Xi’an Jiaotong University from January to June 2022 were collected and analyzed retrospectively.The incidence and occurrence characteristics of hypertension and hypokalemia caused by magnesium isoglycyrrhizinate injection were recorded,and the influencing factors were analyzed.Results Totally 41 cases of hypertension occurred in 300 cases using magnesium isoglycyrrhizinate injection,the incidence rate was 13.67%.Multivariate logistic regression analysis showed that patients with older age(OR=1.028,95%CI 1.001 to 1.058,P=0.049),higher body mass index(OR=1.435,95%CI 1.226 to 1.681,P﹤0.001)and longer course of using magnesium isoglycyrrhizinate injection(OR=1.304,95%CI 1.158 to 1.467,P﹤0.001)may be more likely to induce hypertension when using magnesium isoglycyrrhetate injection.Totally 29 cases of hypokalemia occurred,the incidence rate was 9.67%.Multivariate logistic regression analysis showed that age(OR=1.037,95%CI 1.003 to 1.072,P=0.033),daily dose of magnesium isoglycyrrhizinate injection(OR=1.024,95%CI 1.005 to 1.043,P=0.011)and the course of using magnesium isoglycyrrhizinate injection(OR=1.097,95%CI 1.004 to 1.198,P=0.040)may be the influencing factors of hypokalemia induced by magnesium isoglycyrrhizinate injection.Conclusions The blood pressure and electrolyte levels should be monitored regularly when magnesium isoglycyrrhizinate injection is used for clinical therapy.The patient with older age,higher the body mass index,longer the course of medication,the higher the probability of hypertension when using magnesium isoglycyrrhizate injection.The older the patient,the higher the daily dose and the longer the course of medication,the higher the probability of hypokalemia when usi

关 键 词：异甘草酸镁注射液 高血压 低钾血症 影响因素 

分 类 号：R969[医药卫生—药理学]