八宝丹胶囊治疗急性胆囊炎患者的临床研究  

Clinical trial of Babaodan capsules in the treatment of patients with acute cholecystitis

作　　者：任军帮 沈有秀[1] 张永刚[1] 钱慧岗[1] 韩晓婷 张静妮[2] REN Jun-bang;SHEN You-xiu;ZHANG Yong-gang;QIAN Hui-gang;HAN Xiao-ting;ZHANG Jing-ni(Department of Emergency Surgery,Qinghai Provuincial People's Hospital,Xining 81000,Qinghai Province,China;Department of Hepatological Surgery,Qinghai Provuincial People's Hospital,Xining 81000,Qinghai Province,China;Department of Internal Medicine,Qinghai Women and Children's Hospital,Xining 811602,Qinghai Province,China)

机构地区：[1]青海省人民医院急诊外科,青海西宁810000 [2]青海省人民医院肝胆外科,青海西宁810000 [3]青海省妇女儿童医院内科,青海西宁811602

出　　处：《中国临床药理学杂志》2023年第12期1689-1693,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：目的 观察八宝丹胶囊对急性胆囊炎患者病情控制、胆汁酸(TBA)、淀粉酶、肝功能、免疫功能及炎症因子的影响。方法 将急性胆囊炎患者用随机数字表法分为试验组及对照组。2组均给予基础内科保守治疗,给予左氧氟沙星片,每次0.5 g,每天3次,口服;消炎利胆片,每次1.5 g,每天3次,口服。试验组在基础治疗的基础上给予八宝丹胶囊,每次0.6 g,每天2次,口服。2组均治疗1周。观察2组病情控制情况及中医证候积分变化情况,检测2组患者TBA、淀粉酶、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、谷丙转氨酶(GPT)、谷草转氨酶(GOT)、总胆红素(TBIL)、γ谷氨酰转移酶(γ-GT)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平,记录药物不良反应发生情况。结果 试验组102例,对照组98例。试验组病情控制优良率为97.06%,显著高于对照组的89.80%(P<0.05)。治疗后,试验组和对照组TBA分别为(9.33±1.25)和(12.25±2.47)μmol·L^(-1),淀粉酶分别为(213.26±31.45)和(315.67±32.58)U·L^(-1),IL-6分别为(25.46±3.58)和(37.14±5.33)μg·L^(-1),TNF-α分别为(0.54±0.06)和(1.33±0.14)mmol·L^(-1),CRP分别为(42.16±6.57)和(53.98±6.33)mg·L^(-1),GOT分别为(42.65±5.17)和(62.33±7.45)U·L^(-1),GPT分别为(32.45±5.67)和(54.15±6.87)U·L^(-1),TBIL分别为(17.56±2.69)和(30.54±4.58)μmol·L^(-1),γ-GT分别为(8.33±0.91)和(12.54±2.67)U·L^(-1),IgA分别为(2.54±0.27)和(2.16±0.29)g·L^(-1),IgG分别为(1.43±0.17)和(1.22±0.14)g·L^(-1),IgM分别为(19.14±2.05)和(16.17±2.64)g·L^(-1),差异均有统计学意义(均P<0.05)。2组药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论 八宝丹胶囊可有效控制急性胆囊炎患者病情、改善症状,可能与其能有效降低炎症因子、TBA、淀粉酶水平,改善肝功能指标及免疫功能有关。Objective To observe the effect of Babaodan capsules on disease control,total bile acid(TBA),amylase,liver function,immune function and inflammatory factors in patients with acute cholecystitis.Methods Patients with acute cholecystitis were divided into treatment group and control group by random number table method.All patients were given basic conservative medical treatments,oral administration of levofloxacin tablets,0.5 g a time,3 times a day and oral administration of Xiaoyan Lidan tablets,1.5 g a time,3 times a day.On this basis,the treatment group was treated with Babaodan capsules,0.6 g a time,twice a day,oral.All patients underwent 1 week of treatment.Disease control and changes of traditional Chinese medicine syndrome scores in the two groups were observed.The levels of TBA,amylase,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),glutamate pyruvic transaminase(GPT),glutamic-oxaloacetic transaminase(GOT),total bilirubin(TBIL),-glutamyltransferase(γ-GT),immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)were detected.The incidence of adverse reactions were recorded.Results There were 102 cases in treatment group and 98 cases in control group.The excellent and good rates of disease control in the treatment group and the control group were 97.06%and 89.80%(P<0.05).After treatment,TBA levels in treatment group and control group were(9.33±1.25)and(12.25±2.47)μmol.L^(-1);amylase levels were(213.26±31.45)and(315.67±32.58)U·L-^(-1);IL-6 levels were(25.46±3.58)and(37.14±5.33)μg·L^(-1);TNF-αlevels were(0.54±0.06)and(1.33±0.14)mmol·L-^(-1);CRP levels were(42.16±6.57)and(53.98±6.33)mg·L^(-1);GOT levels were(42.65±5.17)and(62.33±7.45)U·L^(-1);GPT levels were(32.45±5.67)and(54.15±6.87)U·L^(-1);TBIL levels were(17.56±2.69)and(30.54±4.58)μmol·L^(-1);γ-GT levels were(8.33±0.91)and(12.54±2.67)U·L^(-1);IgA levels were(2.54±0.27)and(2.16±0.29)g·L^(-1);IgG levels were(1.43±0.17)and(1.22±0.14)g·L^(-1);IgM levels were(19.14±2.05)and(16.17±2.64

关 键 词：八宝丹胶囊 急性胆囊炎 病情控制 胆汁酸 淀粉酶 肝功能 免疫功能 炎症因子 

分 类 号：R28[医药卫生—中药学]