中药单体成分及复方促进骨折愈合的作用机制研究进展  

Research progress on the mechanism of promoting fracture healing by traditional Chinese medicine monomer components and compound formulas

作　　者：张志宏 孙延平[1] 彭东辉 崔娜 曾元宁 匡海学[1] 王秋红[1] ZHANG Zhihong;SUN Yanping;PENG Donghui;CUI Na;ZENG Yuanning;KUANG Haixue;WANG Qiuhong(Key Laboratory of Basic and Application Research of Beiyao(Ministry of Education),College of Pharmacy,Heilongjiang University of Chinese Medicine,Harbin 150040,China;School of TCM,Guangdong Pharmaceutical University,Guangzhou 510006,China)

机构地区：[1]黑龙江中医药大学药学院教育部北药基础与应用研究重点实验室,哈尔滨150040 [2]广东药科大学中药学院,广州510006

出　　处：《中国药房》2023年第17期2172-2176,共5页China Pharmacy

基　　金：国家重点研发计划项目(No.2018YFC1707100);国家自然科学基金面上项目(No.81773904);国家“重大新药创制”科技重大专项(No.2018ZX09731-001);黑龙江省“头雁”团队支持项目(No.[2019]5号)。

摘　　要：中药在治疗骨折愈合过程中具有多成分、多途径、多靶点的作用特点,对于具有复杂病理机制的骨折具有较好的治疗优势和潜力。笔者对中药单体成分及复方促进骨折愈合的作用机制进行了归纳,发现内脂素A、葛根素等可通过激活丝裂原活化蛋白激酶(MAPK)信号通路,续骨丹、固本增骨方等可通过激活骨形态发生蛋白(BMP)信号通路,黄芩苷、牛膝多糖等可通过激活Wnt/β-catenin信号通路,芹菜素、三七皂苷等可通过激活核因子κB(NF-κB)受体激活蛋白/NF-κB受体激活蛋白配体/护骨因子(RANK/RANKL/OPG)信号通路,活血接骨复方胶囊、健骨颗粒等可通过抑制磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/AKT)信号通路,淫羊藿苷等可通过激活Notch信号通路,桃红四物汤、藏红花素等可通过激活Hippo信号通路,酸枣仁皂苷A、蛇床子素等可通过抑制NF-κB信号通路,发挥促进骨折愈合的作用。Traditional Chinese medicine has the characteristics of multiple components,pathways,and targets in the treatment of fracture healing,and has good therapeutic advantages and potential for fractures with complex pathological mechanisms.Based on this,the author summarized the mechanism of promoting fracture healing by the monomer components and compound formulas of traditional Chinese medicine and found that visfatin A,puerarin,and others can activate the mitogen-activated protein kinase(MAPK) signaling pathway;Xugudan,Guben zenggu formula and others can activate bone morphogenetic protein(BMP) signaling pathway;baicalin,Achyranthes bidentata polysaccharides and others can activate Wnt/β-catenin signaling pathway;apigenin,notoginsenoside and others can activate receptor activator of nuclear factor-κB(NF-κB)/receptor activator of NF-κB ligand/osteoprotegerin(RANK/RANKL/OPG) signaling pathway;Compound huoxue jiegu capsule,Jiangu granule and others can inhibit phosphoinositide 3-kinase/protein kinase B(PI3K/AKT) signaling pathway;icariin can activate Notch signaling pathway;Taohong siwu decoction,crocin and others can activate Hippo signaling pathway;jujuboside A and osthole can inhibit NF-κB signaling pathway,and thus promote fracture healing.

关 键 词：中药 单体成分 复方 骨折愈合 信号通路 成骨分化 

分 类 号：R965[医药卫生—药理学] R285[医药卫生—药学]