Ca^(2+)/CaM依赖性蛋白激酶Ⅱ在心力衰竭中的作用机制及中医药治疗应用进展  

Mechanism of Action of Ca^(2+)/Calmodulin Dependent Protein Kinase Ⅱ in Heart Failure and the Progress of Its Application in Traditional Chinese Medicine Treatment

作　　者：柏婷燕 易希善 赵信科[1] 刘凯[1] 蒋虎刚 李应东[1,2] BAI Tingyan;YI Xishan;ZHAO Xinke;LIU Kai;JIANG Hugang;LI Yingdong(Gansu University of Chinese Medicine,Lanzhou 730000,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃中医药大学附属医院,兰州730000

出　　处：《中国现代应用药学》2023年第14期2023-2031,共9页Chinese Journal of Modern Applied Pharmacy

基　　金：甘肃省中医药防治重大疾病科研课题(GZKZD-2018-2)。

摘　　要：心力衰竭是一种常见的多发病,是各种心脏疾病发展的终末阶段,发病机制十分复杂,严重危害着人类健康。大量研究表明Ca^(2+)/CaM依赖性蛋白激酶Ⅱ(Ca^(2+)/Calmodulin dependent protein kinase Ⅱ,CaMKⅡ)在心力衰竭的发生发展中起着重要的作用。中医药在防治心力衰竭方面具有独特优势和良好前景,其中有不少可靶向调节CaMKⅡ的复方和中药有效成分。本文就CaMKⅡ信号通路在衰竭心脏中的作用机制以及近年来中医药通过靶向调节CaMKⅡ信号防治心力衰竭研究进展作主要阐述,以期为临床中医药防治心力衰竭方面提供参考意见并拓展思路。Heart failure is a common frequently-occurring disease,and it is the terminal stage of the development of various heart diseases.The pathogenesis is very complex and seriously endangers human health.A large number of studies have shown that Ca^(2+)/Calmodulin dependent protein kinase Ⅱ(CaMKⅡ) plays an important role in the occurrence and development of heart failure.Traditional Chinese medicine has unique advantages and good prospects in the prevention and treatment of heart failure.Among them,there are many compound and their active ingredients can target and regulate CaMKⅡ.This paper mainly expounds the mechanism of the CaMKⅡ signaling pathway in the failing heart and the research progress of traditional Chinese medicine in preventing and treating heart failure by targeting the regulation of CaMKⅡ signaling in recent years,in order to provide reference and expand ideas for clinical traditional Chinese medicine prevention and treatment in heart failure.

关 键 词：心力衰竭 CaMKⅡ信号通路 作用机制 中医药 研究进展 

分 类 号：R966[医药卫生—药理学]