银杏叶制剂超说明书使用研究进展  

Research Progress of Ginkgo Biloba Preparation in Off-label Drug Use

作　　者：郑亚纯 杜海程 洪亦超 丁楠 周鑫 王建方 姚建标 ZHENG Yachun;DU Haicheng;HONG Yichao;DING Nan;ZHOU Xin;WANG Jianfang;YAO Jianbiao(Zhejiang CONBA Pharmaceutical Co.,Ltd.,Hangzhou 310052,China)

机构地区：[1]浙江康恩贝制药股份有限公司,杭州310052

出　　处：《中国现代应用药学》2023年第15期2167-2176,共10页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省科技计划项目(2022C03142);浙江省级重点企业研究院(2012Y1038)。

摘　　要：银杏叶制剂是国内外广泛使用的天然提取物制剂,国内主要用作心梗、脑梗疾病的治疗,国外主要用于改善记忆,治疗痴呆症状,近年来也有大量用于眼科疾病、精神疾病、肾病等疾病治疗的报道,其中部分报道结果并不统一。因此需要对银杏叶制剂超说明书使用报道进行总结。其中银杏叶制剂对治疗痴呆症以及自闭症等脑部疾病存在较大争议,主要是由于其作用温和,慢性疾病长期用药数据跟踪困难,认知水平的评测结果较为主观等,因此还需要更多的高水平研究进行数据支撑。此外,银杏叶制剂对周围神经、微血管的保护作用较为明显,在相关疾病中作为辅助用药,可以有效加速患者的康复进程。本文对银杏叶制剂多方面报道进行总结,可以更好地明确产品定位,为相关治疗方案的选择提供参考。Ginkgo biloba preparation is widely used as natural extract preparation both domestically and internationally,for myocardial infarction and cerebral infarction diseases in China;and mainly used to improve memory and treat dementia symptoms abroad.In recent years,there have been a large amount of reports on the treatment of ophthalmic diseases,mental diseases,kidney diseases and so on,however some of which have not uniform literature result.Therefore,it is necessary to summarize the reports on off-label use of Ginkgo biloba preparation.Among them,Ginkgo biloba preparation has a lot of controversy on brain diseases such as dementia and autism,mainly due to the mild effect,the difficulty in tracking long-term medication data for chronic diseases,and the subjective evaluation results of cognitive level,so more high-level research is needed to provide data support.In addition,Ginkgo biloba preparation has obvious protective effects on peripheral nerves and microvascular,and as an adjuvant drug in related diseases,it can effectively accelerate the recovery process of patients.This article summarizes various reports on Ginkgo biloba preparations,which can better clarify the product positioning and provide a reference for the selection of relevant treatment options.

关 键 词：银杏叶 超说明书使用 中枢神经疾病 耳部疾病 眼科疾病 精神疾病 肾病 

分 类 号：R969.3[医药卫生—药理学]