血清sFRP2、omentin-1在肥厚型心肌病的水平及其与炎症因子和心功能指标的关系  

Serum levels of sFRP2 and omentin-1 in patients with hypertrophic cardiomyopathy and its relationship with inflammatory factors and cardiac function indexes

作　　者：钟斌 苏建 张培 ZHONG Bin;SU Jian;ZHANG Pei(Department of Cardiovascular Medicine,Ankang Hospital of Traditional Chinese Medicine,Ankang,Shaanxi 725000,China)

机构地区：[1]安康市中医医院心血管内科,陕西安康725000

出　　处：《检验医学与临床》2023年第17期2557-2560,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨肥厚型心肌病(HCM)患者血清分泌型卷曲相关蛋白2(sFRP2)、网膜素1(omentin-1)水平与炎症因子和心功能指标的关系。方法选取2018年7月至2021年5月安康市中医医院心血管内科收治的HCM患者110例作为HCM组,根据最大左心室壁厚度(LVPWT)分为轻度肥厚组(57例)、中度肥厚组(42例)和重度肥厚组(11例)。另选取同期心功能正常的志愿者64例作为对照组。比较4组一般资料、生化指标和超声心动图检测指标。采用ELISA检测血清sFRP2、omentin-1水平。采用Pearson相关分析HCM患者血清sFRP2、omentin-1水平与炎症因子和心功能指标的相关性。结果与对照组比较,轻度肥厚组、中度肥厚组和重度肥厚组舒张压、收缩压、左心室心肌质量(LVMM)、LVPWT均明显升高,差异均有统计学意义(P<0.05)。4组体质量指数、年龄、性别、总胆固醇、血尿酸等比较,差异均无统计学意义(P>0.05)。与对照组比较,轻度肥厚组、中度肥厚组和重度肥厚组血清sFRP2、omentin-1水平均明显降低,血清白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)水平均明显升高,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,血清sFRP2、omentin-1水平与HCM患者舒张压(r=-0.43、-0.53,P<0.05)、收缩压(r=-0.44、-0.55,P<0.05)、LVMM(r=-0.42、-0.66,P<0.05)、LVPWT(r=-0.44、-0.62,P<0.05)、IL-6(r=-0.42、-0.52,P<0.05)、TNF-α(r=-0.42、-0.58,P<0.05)均呈负相关。结论HCM患者血清sFRP2、omentin-1呈低表达,检测血清sFRP2、omentin-1水平有助于评估HCM的发生、发展进程。Objective To investigate the relationship between serum secreted frizzled-related protein 2(sFRP2)and omentin-1 levels and inflammatory factors and cardiac function in hypertrophic cardiomyopathy(HCM)patients.Methods A total of 110 HCM patients admitted to the Department of Cardiology of Ankang Hospital of Traditional Chinese Medicine from July 2018 to May 2021 were selected as the HCM group.According to the maximum left ventricular posterior wall thickness(LVPWT),they were divided into mild hypertrophy group(57 cases),moderate hypertrophy group(42 cases)and severe hypertrophy group(11 cases).Another 64 volunteers with normal cardiac function during the same period were selected as the control group.The general data,biochemical indicators and echocardiographic indicators of the 4 groups were compared.ELISA was used to detect the levels of serum sFRP2 and omentin-1.Pearson correlation analysis was used to analyze the correlation between serum sFRP2,omentin-1 levels and inflammatory factors and cardiac function indexes in HCM patients.Results Compared with the control group,the diastolic blood pressure,systolic blood pressure,left ventricular myocardial mass(LVMM)and LVPWT in the mild hypertrophy group,moderate hypertrophy group and severe hypertrophy group were significantly increased(P<0.05).There was no significant difference in body mass index,age,sex,total cholesterol and blood uric acid among the 4 groups(P>0.05).Compared with the control group,the mild hypertrophy group,the moderate hypertrophy group and the severe hypertrophy group had significantly lower serum levels of sFRP2 and omentin-1 and significantly higher serum levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)(P<0.05).Pearson correlation analysis showed that serum sFRP2 and omentin-1 expression levels were associated with diastolic blood pressure(r=-0.43,-0.53,P<0.05),systolic blood pressure(r=-0.44,-0.55,P<0.05),LVMM(r=-0.42,-0.66,P<0.05),LVPWT(r=-0.44,-0.62,P<0.05),IL-6(r=-0.42,-0.52,P<0.05)and TNF-α(r=-0.42,-0.58,P<0.05)showed

关 键 词：肥厚型心肌病 分泌型卷曲相关蛋白2 网膜素1 炎症因子 心功能 

分 类 号：R542.2[医药卫生—心血管疾病]