低密度脂蛋白胆固醇直接检测方法与间接计算公式  

Quantitative detection and calculation formula of low density lipoprotein cholesterol

作　　者：敖登托娅(综述) 王美英(审校)[2] AODENG Tuoya;WANG Meiying(Department of Clinical Laboratory,the Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Mongolia 010090,China;Department of Clinical Laboratory,Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Mongolia 010010,China)

机构地区：[1]内蒙古医科大学第二附属医院检验科,内蒙古呼和浩特010090 [2]内蒙古医科大学附属医院检验科,内蒙古呼和浩特010010

出　　处：《检验医学与临床》2023年第17期2578-2582,共5页Laboratory Medicine and Clinic

基　　金：内蒙古自治区卫生健康科技计划项目(202201260)。

摘　　要：低密度脂蛋白胆固醇定量检测的参考方法是超高速离心法,但该方法操作繁琐且耗时较长,并不适用于普通的临床实验室。均相法是一种自动化的低密度脂蛋白胆固醇定量检测方法,具有快速、便捷等优点,但该方法与超高速离心法之间有一定的偏差。为了节约成本,部分血脂实验室采用的是运用公式来间接计算低密度脂蛋白胆固醇水平。其中最常用的公式包括:Friedewald公式、Martin-Hopkins公式、Sampson公式。此外,还有多项研究利用机器学习等人工智能手段计算低密度脂蛋白胆固醇水平。本文综述了低密度脂蛋白胆固醇的检测方法,以及目前3种常用的计算公式及机器学习在计算低密度脂蛋白胆固醇水平中的应用。The reference method for quantitative detection of low density lipoprotein cholesterol is ultracentrifugation,which is cumbersome and time-consuming,and it is not suitable for application in common clinical laboratories.Homogeneous assay is an automatic quantitative detection method for low density lipoprotein cholesterol,which is rapid and easy to perform,however,there is a certain deviation between this method and ultracentrifugation.In order to save costs,some lipid laboratories use formulas to indirectly calculate low density lipoprotein cholesterol level.The most commonly used formulas include:Friedewald formula,Martin-Hopkins formula,and Sampson formula.In addition,a number of studies have used artificial intelligence methods such as machine learning to calculate low density lipoprotein cholesterol level.This paper reviews 3 commonly used calculation formulas and the application of machine learning in the calculation of low density lipoprotein cholesterol level.

关 键 词：低密度脂蛋白胆固醇 均相法 超高速离心 计算公式 

分 类 号：R446.112[医药卫生—诊断学]