铜死亡与铜复合物抗肿瘤治疗研究进展  

Research advances of cuproptosis and copper complexes in antitumor therapy

作　　者：刘炜 张杨秋蓉 李莉[1] 曹俊宇 陈锡华 杨昆宪[1] LIU Wei;ZHANG Yangqiurong;LI Li;CAO Junyu;CHEN Xihua;YANG Kunxian(Department of Breast and Thyroid Surgery,the First People's Hospital of Yunnan Province,Yunnan Kunming 650034,China;Department of General Surgery,the People's Hospital of Mouding County,Yunnan Chuxiong 675500,China)

机构地区：[1]云南省第一人民医院乳腺甲状腺外科,云南昆明650034 [2]牟定县人民医院普外科,云南楚雄675500

出　　处：《现代肿瘤医学》2023年第18期3502-3507,共6页Journal of Modern Oncology

基　　金：国家自然科学基金青年项目(编号:82002812);昆明医科大学应用基础研究联合专项(编号:202101AY070001-239)。

摘　　要：铜在各种生理过程中发挥着重要的作用,铜的稳态受到严格调控以限制氧化应激的产生和毒性,血清和组织中升高的铜含量与肿瘤的发生、进展、转移相关。针对铜的靶向治疗已成为一种抗肿瘤的新策略。铜死亡是一种全新的、不同于已知的调节性细胞死亡(regulatory cell death,RCD)的、铜依赖性的细胞死亡方式,为铜稳态与线粒体代谢之间的联系提供了新的视角。本文对铜死亡与铜复合物抗肿瘤治疗的研究现状进行简要综述。Copper(Cu)is critical for various physiological processes,and copper homeostasis is tightly regulated to limit oxidative stress production and toxicity.Elevated Cu content in serum and tumor tissues is correlated with tumorigenesis,cancer progression and metastasis.Hence,targeting copper therapy has emerged as a new strategy in antitumor therapy.Cuproptosis is a novel,distinct from all other known regulatory cell death(RCD),copper-dependent cell death modality,which provides a novel perspective for the connection between copper homeostasis and mitochondrial metabolism.This article reviews the research progress of cuproptosis and copper complexes in antitumor therapy.

关 键 词：铜死亡 铜复合物 铜稳态 细胞死亡 抗肿瘤治疗 

分 类 号：R730.5[医药卫生—肿瘤]