舒肝宁注射液联合水溶性维生素治疗急性酒精中毒的效果  

Effect of Shuganning Injections combined with water-soluble vitamins in the treatment of acute alcoholism

作　　者：郭志丽 李淑静 于丽娜 杨宽 翟晓丹 GUO Zhili;LI Shujing;YU Li na;YANG Kuan;ZHAI Xiaodan(Department of Emergency,the Second Hospital of Zhangjiakou,Zhangjiakou 075000,China;Department of Intensive Care Medicine,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]张家口市第二医院急诊科,张家口075000 [2]河北北方学院附属第一医院重症医学科,张家口075000

出　　处：《西北药学杂志》2023年第5期171-175,共5页Northwest Pharmaceutical Journal

基　　金：张家口市重点研发计划项目(编号:2121101D)。

摘　　要：目的探究舒肝宁注射液联合水溶性维生素对急性酒精中毒患者心肌酶活性、神经递质水平的影响及治疗效果。方法选取就诊的急性酒精中毒患者80例,用简单随机法分为观察组(n=40)和对照组(n=40)。对照组用纳洛酮注射液联合补液治疗,观察组在对照组治疗的基础上联合舒肝宁注射液和水溶性维生素治疗,2组患者均治疗3 d。比较2组患者的临床疗效、体内酒精质量浓度[呼气酒精质量浓度测量情况(breath alcohol concentration,BrAC)],比较治疗前及治疗3 d后心肌酶活性[天冬氨酸氨基转移酶(aspartate aminotransferase,AST)、肌酸激酶(creatine kinase,CK)和肌钙蛋白(cardiac troponin,cTnI)]、神经递质指标[诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)、多巴胺(dopamine,DA)、去甲肾上腺素(norepinephrine,NE)和血管加压素(arginine vasopressin,AVP)]以及肝肾功能[血清总蛋白(serum total protein,STP)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、血尿素氮(blood urea nitrogen,BUN)和血肌酐(serum creatinine,Scr)]水平的变化,并记录患者治疗苏醒后的不良反应发生情况。结果治疗3 d后,观察组的临床总有效率(92.5%)明显高于对照组(75.0%),χ^(2)=4.501,P=0.034。治疗12 h后,观察组的BrAC(t=6.853,P=0.000)明显低于对照组;2组患者的AST、CK和cTnI均较治疗前明显降低,且观察组均明显低于对照组(t=14.457,P=0.000;t=6.083,P=0.000;t=9.804,P=0.000);2组患者的NOS、DA、NE和AVP均较治疗前明显降低,且观察组均明显低于对照组(t=4.555,P=0.000;t=3.172,P=0.002;t=2.765,P=0.007;t=3.597,P=0.001);2组患者STP、ALT、BUN、Scr均较治疗前明显降低,且观察组均明显低于对照组(t=4.677,P=0.000;t=3.854,P=0.000;t=3.127,P=0.002;t=6.969,P=0.000);观察组苏醒后总不良反应发生率(17.5%)明显低于对照组(37.5%),χ^(2)=4.013,P=0.045。结论舒肝宁注射液联合水溶性维生素治疗急性酒精中毒可有效提高患者的认知功能,Objective To explore the influence and therapeutic effect of Shuganning Injections combined with water-soluble vitamins on myocardial enzyme activity and on the levels of neurotransmitters in patients with acute alcoholism.Methods A total of 80 patients with acute alcoholism were selected and divided into observation group(n=40)and control group(n=40)by simple random method.The control group was treated with Naloxone Injections combined with liquid infusion,while the observation group was combined with Shuganning Injections and water-soluble vitamins on the basis of the control group.The both groups were treated for 3 days.The clinical efficacy and body alcohol concentration[breath alcohol concentration(BrAC)],and changes in myo-cardial enzyme activity[aspartate aminotransferase(AST),creatine kinase(CK),and cardiac troponin(cTnI)],neurotransmitters indicators[inducible nitric oxide synthase(iNOS),dopamine(DA),norepinephrine(NE),and arginine vasopressin(AVP)]and liver-kidney function indicators[serum total protein(STP),alanine aminotransferase(ALT),blood urea nitrogen(BUN),and serum creatinine(Scr)]before treatment and after 3 days of treatment were compared between the 2 groups.The occurrence of adverse reactions was recorded after resuscitation.Results After 3 days of treatment,the total clinical effective rate(92.5%)of the observation group was significantly higher than that of the control group(75.0%),χ^(2)=4.501,P=0.034.The concentration of BrAC in observation group after 12 hours of treatment was significantly lower than that in control group,t=6.853,P=0.000.The AST,CK and cTnI in both groups after 3 days of treatment were significantly reduced compared with those before treatment,and the above indicators were lower in the observation group(t=14.457,P=0.000;t=6.083,P=0.000;t=9.804,P=0.000).The NOS,DA,NE,and AVP in both groups after 3 days of treatment were significantly reduced compared with those before treatment,and the above indicators were lower in the observation group(t=4.555,P=0.000;t=3.172,P=0.002;t

关 键 词：舒肝宁注射液 维生素C 维生素B_(6) 急性酒精中毒 心肌酶 神经递质 

分 类 号：R975[医药卫生—药品]