左旋甲状腺素对妊娠合并甲减患者甲状腺功能及母婴结局的影响分析  

Effect of levothyroxine on thyroid function and maternal and fetal outcomes in pregnant women with hypothyroidism

作　　者：朱冬梅 Zhu Dongmei(Department of Obstetrics and Gynecology,Yancheng Dafeng People's Hospital,Yancheng 224100,China)

机构地区：[1]盐城市大丰人民医院妇产科,江苏盐城224100

出　　处：《实用妇科内分泌电子杂志》2023年第14期90-92,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探讨左旋甲状腺素在治疗妊娠合并甲状腺功能减退症(甲减)的效果及对患者甲状腺功能、母婴结局的影响。方法选取60例妊娠合并甲减患者,根据治疗方法不同分为对照组与研究组,每组30例。对照组采用甲状腺片治疗,研究组采用左旋甲状腺素治疗。比较两组甲状腺功能、母婴结局。结果治疗前,两组促甲状腺激素(TSH)、血清游离三碘甲腺原氨酸(FT_(3))及血清游离甲状腺素(FT_(4))指标比较,差异无统计学意义(P>0.05);治疗后,两组TSH指标均较治疗前明显降低,FT_(3)及FT_(4)指标升高,且研究组TSH指标低于对照组,FT_(3)及FT_(4)指标高于对照组,差异具有统计学意义(P<0.05)。研究组不良母婴结局发生率6.67%明显低于对照组的26.67%,差异具有统计学意义(P<0.05)。结论在治疗妊娠合并甲减患者时可有效考虑口服左旋甲状腺素,对改善甲状腺功能及母婴结局具有重要价值。Objective To investigate the effect of levothyroxine in the treatment of pregnant women with hypothyroidism(hypothyroidism)and its influence on thyroid function and maternal and infant outcomes.Methods 60 pregnant patients with hypothyroidism were selected and divided into control group and study group according to different treatment methods,with 30 cases in each group.The control group was treated with thyroxine tablets,and the study group was treated with levothyroxine.Thyroid function and maternal and infant outcomes were compared between the two groups.Results Before treatment,there was no significant difference in thyroid stimulating hormone(TSH),serum free triodothyronine(FT_(3))and serum free thyroxine(FT_(4))between 2 groups(P>0.05).After treatment,TSH indexes in both groups were significantly lower than before treatment,and FT_(3),and FT_(4) indexes were increased,and TSH indexes in the study group were lower than those in the control group,while FT_(3),and FT_(4) indexes were higher than those in the control group,with statistical significance(P<0.05).The incidence of adverse maternal and infant outcomes in the study group(6.67%)was significantly lower than that in the control group(26.67%),and the difference was statistically significant(P<0.05).Conclusion Oral levothyroxine can be effectively considered in the treatment of pregnant patients with hypothyroidism,which has important value in improving thyroid function and maternal and infant outcomes.

关 键 词：左旋甲状腺素 妊娠合并甲状腺功能减退症 母婴结局 

分 类 号：R714.256[医药卫生—妇产科学]