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作 者:石颖 於江泉[1] 张文娟[1] SHI Ying;YU Jiangquan;ZHANG Wenjuan(Department of Critical Care Medicine,Northern Jiangsu People′s Hospital of Jiangsu Province,Yangzhou,Jiangsu,225002)
机构地区:[1]江苏省苏北人民医院重症医学科,江苏扬州225002
出 处:《实用临床医药杂志》2023年第14期121-125,共5页Journal of Clinical Medicine in Practice
基 金:江苏省第六期“333高层次人才培养工程”第三层次人才项目;江苏省高层次卫生人才“六个一工程”拔尖人才科研项目(LGY2019036);江苏省医学重点学科项目(JSDW20221);江苏省苏北人民医院青年托举专项基金(SBQN22025)。
摘 要:脓毒症发病率高,缺乏有效治疗方法,是重症监护室患者死亡的主要原因。内质网是一种细胞器,发挥促进蛋白质折叠和组装等一系列生理活动的作用。在一定条件下,内质网会失去稳态,导致未折叠或错误折叠蛋白的积累,称为内质网应激(ERs)。ERs与脓毒症及由其引起的器官功能障碍有关。本文综述了目前ERs、未折叠蛋白反应(UPR)信号通路与脓毒症相关的研究进展,同时探讨了ERs作为脓毒症治疗靶点的潜在意义及其未来发展方向。Sepsis has high incidence and lack of effective treatment,and it is the leading cause of death in intensive care unit.The endoplasmic reticulum is an organelle,and it is responsible for a series of physiological activities such as protein folding and assembly.Under certain conditions,the endoplasmic reticulum can lose homeostasis,leading to the accumulation of unfolded or misfolded proteins,which is known as endoplasmic reticulum stress(ERs).ERs is associated with sepsis and its related organ dysfunction.This review reviewed the recent advances in ERs,unfolded protein response(UPR)signaling pathways related to sepsis.At the same time,the potential significance of ERs as a therapeutic target for sepsis and its future development direction were discussed.
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