疏凿饮子加减治疗慢性肾小球肾炎的临床研究  

Clinical Research on Modified Shuzao Yinzi in the Treatment of Chronic Glomerulonephritis

作　　者：裴国超[1] 赵丽[1] 马金荣[1] 潘红梅[1] PEI Guochao;ZHAO Li;MA Jinrong;PAN Hongmei(Dept.of Nephrology,Cangzhou Hospital of Integrated TCM-WM,Hebei Cangzhou 061000,China)

机构地区：[1]河北省沧州中西医结合医院肾病科,河北沧州061000

出　　处：《中国医院用药评价与分析》2023年第8期963-966,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省中医药管理局课题(No.2019303)。

摘　　要：目的:从“实”论治探讨疏凿饮子加减治疗慢性肾小球肾炎的临床疗效。方法:选择2020年1月至2022年4月于该院就诊的慢性肾小球肾炎患者92例,根据随机数字表法分为对照组与治疗组,各46例。对照组患者给予盐酸贝那普利片治疗,治疗组患者在对照组的基础上加用疏凿饮子加减。观察两组患者治疗前后的临床疗效、中医证候评分、肾功能指标[血清尿素氮(BUN)、血肌酐(SCr)、24 h尿蛋白定量和肾小球滤过率]水平、尿常规[尿液中白细胞计数、尿液中红细胞计数]及肾脏血流动力学指标[收缩期峰值流速(PSFV)、舒张期末血流速度(EDFV)、搏动指数(PI)和阻力指数(RI)]水平。结果:治疗后,治疗组患者的总有效率为93.48%(43/46),显著高于对照组[78.26%(36/46)],差异有统计学意义(P<0.05)。治疗后,两组患者面目肢体浮肿评分、腰部刺痛评分、咽喉肿痛评分和口黏纳呆评分均较治疗前降低,且治疗组患者低于对照组;治疗后,两组患者BUN、SCr和24 h尿蛋白定量水平较治疗前降低,肾小球滤过率较治疗前升高,且治疗组患者优于对照组;治疗后,两组患者尿液中白细胞计数、红细胞计数均较治疗前降低,且治疗组患者低于对照组;治疗后,两组患者PSFV、EDFV水平较治疗前升高,PI、RI水平较治疗前降低,且治疗组患者优于对照组,上述差异均有统计学意义(P<0.05)。结论:疏凿饮子加减治疗慢性肾小球肾炎的临床疗效显著。OBJECTIVE:To probe into the clinical efficacy of modified Shuzao Yinzi in the treatment of chronic glomerulonephritis from the perspective of“real”diagnosis and treatment.METHODS:A total of 92 patients with chronic glomerulonephritis admitted into hospital from Jan.2020 to Apr.2022 were selected and randomly divided into control group and treatment group via random number table method,with 46 cases in each group.The control group was given Benazepril hydrochloride tablets,while the treatment group was given modified Shuzao Yinzi based on the control group.The clinical efficacy,TCM syndrome score,renal function level[blood urea nitrogen(BUN),serum creatinine(SCr),24 h urine protein quantitation and glomerular filtration rate],routine urine examination[white blood cell count and red blood cell count in urine]and renal hemodynamic indicators[peak systolic flow velocity(PSFV),end-diastolic blood flow velocity(EDFV),pulsatility index(PI),resistance index(RI)]of both groups were observed before and after treatment.RESULTS:After treatment,the total effective rate of the treatment group was 93.48%(43/46),which was significantly higher than that of the control group(78.26%,36/46),with statistically significant difference(P<0.05).After treatment,the scores of facial and limb edema,lower back stabbing pain,swollen sore throat,indigestion and loss of appetite in both groups were significantly lower than those before treatment,and those of the treatment group were lower than the control group;after treatment,the BUN,SCr and 24 h urine protein quantitation in both groups were lower than those before treatment,the glomerular filtration rate was higher than that before treatment,and those of the treatment group were better than the control group;after treatment,the white blood cell count and red blood cell count in urine in both groups were lower than those before treatment,and those of the treatment group were better than the control group;after treatment,the PSFV and EDFV values in both groups were higher than those before

关 键 词：疏凿饮子 慢性肾小球肾炎 肾功能 临床观察 

分 类 号：R932[医药卫生—生药学]