多囊卵巢综合征患者行体外受精-胚胎移植前药物预处理的研究进展  

Progress of Pharmacological Pretreatment Before in Vitro Fertilization-Embryo Transfer in Patients with Polycystic Ovarian Syndrome

作　　者：徐丽娟 张燊 何帆[1] XU Lijuan;ZHANG Shen;HE Fan(Dept.of Obstetrics and Gynecology,the Center for Reproductive Medicine,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院妇产科生殖医学中心,重庆400010

出　　处：《中国医院用药评价与分析》2023年第8期1020-1024,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家自然科学基金项目(No.82101710);重庆医科大学附属第二医院“宽仁英才”项目。

摘　　要：多囊卵巢综合征(PCOS)是女性常见的生殖内分泌代谢性疾病。部分PCOS患者因不孕需行体外受精-胚胎移植(IVF-ET)助孕。文献报道,PCOS患者在IVF助孕后发生卵巢过度刺激综合征、流产、极早产、妊娠期糖尿病和妊娠期高血压疾病的风险显著增加。在IVF助孕前给予药物预处理可能是改善PCOS患者妊娠结局的有效手段。本文对相关研究进行综述后发现,采用口服避孕药、二甲双胍、肌醇、生长激素或维生素D预处理,或在控制性促排卵期间应用前述药物,能改善PCOS患者的IVF结局。Polycystic ovarian syndrome(PCOS)is a common female disorder with reproductive,endocrine and metabolic features.Women with PCOS and anovulatory infertility could be offered in vitro fertilization-embryo transfer(IVF-ET)as fertility treatment.A significantly increased risk of ovarian hyperstimulation syndrome,miscarriage,very preterm delivery,gestational diabetes mellitus and hypertensive disorders has been reported to be associated with PCOS in women undergoing IVF.Pharmacological pretreatment before IVF may improve pregnancy outcomes in patients with PCOS.According to review,it is found that preconditioning with oral contraceptives,metformin,inositol,growth hormone,or vitamin D,or during controlled ovulation,could improve IVF outcomes in patients with PCOS.

关 键 词：多囊卵巢综合征 体外受精 胚胎移植 避孕药 二甲双胍 肌醇 生长激素 维生素D 

分 类 号：R97[医药卫生—药品]