小麦麸皮油对肥胖大鼠的减肥降脂作用  

Effects of Wheat Bran Oil on Weight Loss and Lipid Reduction in Obese Rats

作　　者：严欢 杨中[2] 韩加[1] YAN Huan;YANG Zhong;HAN Jia(School of Public Health,Xinjiang Medical University,Urumqi 830017,China;Xinjiang Uygur Autonomous Region Analysis and Testing Research Institute,Xinjiang Key Laboratory of Featured Functional Food Nutrition and Safety Testing,Urumqi 830011,China)

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830017 [2]新疆分析测试研究院新疆特色功能食品营养与安全检测重点实验室,新疆乌鲁木齐830011

出　　处：《食品科技》2023年第6期173-179,共7页Food Science and Technology

基　　金：新疆维吾尔自治区自然科学计划(自然科学基金)面上项目(2021D01A139);“天山创新团队计划”项目(2021D14020)。

摘　　要：目的:建立高脂饮食诱导的肥胖大鼠模型,研究小麦麸皮油(Wheat bran oil,WBO)的减肥降脂作用。方法:取10只正常大鼠作为空白对照组,饲以基础饲料;筛选50只造模成功的肥胖大鼠随机分为5组(每组10只):模型组(蒸馏水5.0 mL/kg),阳性对照亚油酸(Linoleic acid,LA)组(0.07g/kg),WBO低、中、高(1.25、2.50、5.00 g/kg)剂量组,饲以高脂饲料,灌胃给药;空白对照组以蒸馏水(5.0 mL/kg)灌胃,干预9周。每周测量大鼠的体质量、食物效应比,结束后测定体脂、肝脏质量,计算肝脏系数、肥胖指数;取血清测定血生化指标;取肝匀浆测定抗炎、抗氧化及肥胖相关参数;取部分肝脏进行组织病理学检查。结果:WBO可起到减肥、降脂、抗炎和保肝的作用。结论:WBO具有开发成为减肥降脂功能性食品的潜力,研究结果为科学合理开发小麦麸皮提供理论基础。Objective:To establish a high-fat diet induced obesity rat model and study the weight loss and lipid-lowering effects of wheat bran oil(WBO).Method:Ten normal rats were selected as a blank control group and fed with basic feed;50 obese rats were randomly divided into 5 groups(10 rats in each group):model group(distilled water 5.0 mL/kg),positive control linoleic acid(LA)group(0.07 g/kg),WBO low,medium and high(1.25,2.50,5.00 g/kg)dose groups,fed with high-fat diet and administered by gavage.The blank control group was gavaged with distilled water(5.0 mL/kg)for nine weeks of intervention.Measure the body mass and food effect ratio of rats every week,measure body fat and liver mass after completion,calculate liver coefficient and obesity index.Take serum to measure blood biochemical indicators.Take liver homogenate to measure anti-inflammatory,antioxidant,and obesity related parameters.Part of the liver was taken for histopathological examination.Result:WBO can play a role in weight loss,lipidlowering,anti-inflammatory,and liver protection.Conclusion:WBO has the potential to be developed as a functional food for weight loss and lipid reduction,and the research results provide a theoretical basis for the scientific and rational development of wheat bran.

关 键 词：小麦麸皮油 亚油酸 肥胖大鼠 减肥 降脂作用 

分 类 号：TS210.9[轻工技术与工程—粮食、油脂及植物蛋白工程]