加味清心汤联合左乙拉西坦治疗成人癫痫全面强直-阵挛性发作气血两虚证的疗效及对患者脑电图痫性活动的影响  

The Therapeutic Effect of Jiawei Qingxin Decoction(加味清心汤)Combined with Levetiracetam in the Treatment of Adult Epilepsy with Generalized Tonic-Clonic Seizures of Qi and Blood Deficiency Syndrome and Its Influence on Epileptic Activity of Patients with Electroencephalogram(EEG)

作　　者：曾纪超 李爱民[1] 李莲英 黎胜驹 洪荣庆 ZENG Jichao;LI Aimin;LI Lianying;LI Shengju;HONG Rongqing(Yangjiang Hospital of Traditional Chinese Medicine,Guangzhou University of Traditional Chinese Medicine,Yangjiang Guangdong 529500,China)

机构地区：[1]广州中医药大学附属阳江市中医医院,广东阳江529500

出　　处：《中医药导报》2023年第8期44-47,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广东省中医药局科研项目(20202250)。

摘　　要：目的:观察加味清心汤联合左乙拉西坦治疗成人癫痫全面强直-阵挛性发作(GTCS)气血两虚证的疗效及对患者脑电图痫性活动的影响。方法:纳入116例成人癫痫GTCS气血两虚证患者,采用随机数字表法分为对照组和治疗组各58例。对照组患者给予左乙拉西坦治疗,治疗组患者加用加味清心汤治疗。比较两组GTCS患者发作情况、简易精神状态检查量表(MMSE)评分、脑电图情况、血清相关因子及中医证候积分,并统计两组GTCS患者疗效、不良反应。结果:治疗组总有效率为91.38%(53/58),对照组总有效率为77.59%(45/58),治疗组优于对照组(P<0.05)。两组患者治疗后MMSE评分、血清SOD均高于治疗前,每月发作频率、发作持续时间、中医证候积分均低于治疗前,差异均有统计学意义(P<0.05);治疗组患者治疗后MMSE评分、血清SOD均高于对照组,每月发作频率、发作持续时间、中医证候积分均低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后脑电图痫样放电、累及导联数均低于治疗前,差异均有统计学意义(P<0.05);治疗组患者治疗后脑电图痫样放电、累及导联数均低于对照组,差异均有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论:加味清心汤联合左乙拉西坦治疗成人癫痫GTCS气血两虚证有较好疗效,可调节血清SOD的表达,减轻脑电图痫性活动。Objective:To observe the efficacy of Jiawei Qingxin Decoction combined with levetiracetam in the treatment of adult generalized tonic-clonic seizures(GTCS)with qi and blood deficiency syndrome,and its impact on the epileptic activity of the patient's EEG.Methods:A total of 116 adult epilepsy GTCS patients with Qi and blood deficiency syndrome were included and randomly divided into control group and treatment group,with 58 cases in each group by using a random number table method.The control group patients were treated with levetiracetam,while the treatment group patients were treated with Jiawei Qingxin Decoction.Compare the seizure status,Simplified Mental State Examination(MMSE)score,electroencephalogram(EEG),serum related factors,and traditional Chinese medicine syndrome scores of two groups of GTCS patients,and calculate the efficacy and adverse reactions of the two groups of GTCS patients.Results:The total effective rate of the treatment group was 91.38%(53/58),while the total effective rate of the control group was 77.59%(45/58).The treatment group was superior to the control group(P<0.05).After treatment,the MMSE score and serum SOD of the two groups of patients were higher than before treatment,and the monthly seizure frequency,duration of seizures,and TCM syndrome score were lower than before treatment,and the difference was statistically significant(P<0.05).After treatment,the MMSE score and serum SOD of the treatment group were higher than those of the control group,and the monthly seizure frequency,duration of seizure,and TCM syndrome score of the attack were lower than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the number of epileptiform discharges and involved leads in the EEG of the two groups of patients were lower than before treatment,and the differences was statistically significant(P<0.05).After treatment,the epileptiform discharge and the number of involved leads in the EEG of patients in the treatment group were lower than those in th

关 键 词：癫痫 全面强直-阵挛性发作 成人 气血两虚证 加味清心汤 左乙拉西坦 脑电图痫性活动 安全性 

分 类 号：R277.7[医药卫生—中医学]