LISA技术联合NCPAP治疗新生儿呼吸窘迫综合征的有效性分析  

Analysis of Effectiveness of LISA Technique Combined with NCPAP in the Treatment of Neonatal Respiratory Distress Syndrome

作　　者：肖贝如 李帅 钟嘉欣 李琴 黄珊华 许钰枚 XIAO Beiru;LI Shuai;ZHONG Jiaxin;LI Qin;HUANG Shanhua;XU Yumei(People's Hospital of Yangjiang,Yangjiang 529500,China;不详)

机构地区：[1]阳江市人民医院,广东阳江529500

出　　处：《中外医学研究》2023年第23期151-154,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：阳江市医疗卫生类科技计划项目(SF2021066)。

摘　　要：目的:探究经胃管注入肺表面活性物质(pulmonary surfactant,PS)治疗(LISA技术)联合新生儿持续气道正压通气(neonatal continuous positive airway pressure ventilation,NCPAP)治疗新生儿呼吸窘迫综合征的有效性。方法:选取2021年7月-2022年10月于阳江市人民医院就诊的80例符合入组标准的呼吸窘迫综合征新生儿作为本次研究对象。根据随机数表法将患儿分为对照组和研究组,各40例。研究组应用LISA技术联合NCPAP治疗,对照组应用经气管插管注入PS技术(INSURE技术)联合NCPAP治疗。比较两组治疗前后动脉血气指标、近期治疗效果及并发症发生情况。结果:两组治疗前及治疗后1 h、12 h、24 h血p H值、动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))和动脉血二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO_(2))比较,差异无统计学意义(P>0.05);治疗后1 h、12 h、24 h,两组血pH值、PaO2较治疗前均升高,PaCO_(2)较治疗前均降低,差异有统计学意义(P<0.05)。研究组治疗总有效率为92.5%,高于对照组的85.0%,但两组比较差异无统计学意义(P>0.05)。研究组并发症发生率为7.5%,显著低于对照组的32.5%,差异有统计学意义(P<0.05)。结论:LISA技术联合NCPAP方案治疗新生儿呼吸窘迫综合征有良好的效果,可以有效改善血pH值、PaO_(2)及PaCO_(2)水平,降低术后并发症发生率。Objective:To explore the effectiveness of transgastric tube injection of pulmonary surfactant(PS)treatment(LISA technology)combined with neonatal continuous positive airway pressure ventilation(NCPAP)in the treatment of neonatal respiratory distress syndrome.Method:Eighty newborns with respiratory distress syndrome who met the enrollment criteria and were treated in People's Hospital of Yangjiang from July 2021 to October 2022 were selected as the subjects of this study.According to the random number table method,the children were divided into the control group and the study group,40 cases in each group.The study group was given LISA technology and NCPAP treatment,the control group was given with endotracheal intubation PS(INSURE technology)combined with NCPAP treatment.The arterial blood gas indexes before and after treatment,recent treatment effect and complications of two groups were compared.Result:There were no significant differences in blood pH value,arterial partial pressure of oxygen(PaO_(2))and arterial partial pressure of carbon dioxide(PaCO_(2))between two groups before treatment and 1 h,12 h and 24 h after treatment(P>0.05);at 1 h,12 h and 24 h after treatment,the blood pH value and PaO_(2) of two groups were higher than those before treatment,and PaCO_(2) were lower than those before treatment,the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group was 92.5%,which was higher than 85.0% in the control group,but there was no significant difference between two groups(P>0.05).The complication rate in the study group was 7.5%,which was significantly lower than 32.5% of the control group,and the difference was statistically significant(P<0.05).Conclusion:LISA technology combined with NCPAP regimen has a good effect in the treatment of neonatal respiratory distress syndrome,it can effectively improve the blood pH value,PaO_(2) and PaCO_(2) levels,and reduce the incidence of postoperative complications.

关 键 词：经胃管注入肺表面活性物质治疗 经气管插管注入肺表面活性物质技术 新生儿持续气道正压通气 动脉血气指标 

分 类 号：R722.1[医药卫生—儿科]