酚妥拉明、硫酸镁、硝苯地平三联用药对妊娠期高血压患者血清BNP、胱抑素C、D二聚体的影响  

Effect of phentolamine,magnesium sulfate,and nifedipine on serum BNP,cystatin C,and D dimers in patients with pregnancy-induced hypertension

作　　者：张丽丽 冀俊琴 田乃花 ZHANG Lili;JI Junqin;TIAN Naihua(Department of Obstetrics,Shanxi Fenyang Hospital,Fenyang 032200,Shanxi China;Department of Oncology,Shanxi Fenyang Hospital,Fenyang 032200,Shanxi,China;Department of EEG,Shanxi Fenyang Hospital,Fenyang 032200,Shanxi,China)

机构地区：[1]山西省汾阳医院产科,山西汾阳032200 [2]山西省汾阳医院肿瘤科,山西汾阳032200 [3]山西省汾阳医院心电图科,山西汾阳032200

出　　处：《贵州医科大学学报》2023年第8期969-973,共5页Journal of Guizhou Medical University

基　　金：山西省自然科学基金项目(2020011039)。

摘　　要：目的探索酚妥拉明、硫酸镁、硝苯地平三联用药对妊娠期高血压患者血清B型利钠肽(BNP)、胱抑素C(Cys C)及D二聚体(D-D)的影响。方法500例妊娠期高血压疾病患者根据治疗方法均分为观察组和对照组,观察组采用三联用药(酚妥拉明、硫酸镁及硝苯地平)治疗,对照组采用硫酸镁联合硝苯地平治疗,2组均治疗7 d;比较治疗前后2组患者的血清BNP、CysC、D-D、血肌酐及血细胞比积、血液黏稠度、阻力指数、收缩压与舒张压比值等血流动力学变化,比较治疗后2组患者的疾病缓解率及不良反应发生率。结果治疗前两组孕妇Cys C、D-D、Scr、BNP、血细胞比积、血液黏稠度、阻力指数、收缩压与舒张压比值水平比较,差异无统计学意义(P>0.05);治疗后,2组孕妇的血清Cys C、D-D、Scr、BNP水平及血细胞比积、血液粘稠度、阻力指数、收缩压与舒张压比值均治疗前降低(P<0.05),观察组血清Cys C、D-D、Scr、BNP水平及血细胞比积、血液黏稠度、阻力指数、收缩压与舒张压比值均低于对照组(P<0.05);观察组治疗后第1、第3及第7天的疾病缓解率均高于对照组(χ^(2)=25.194、24.754、26.699;P<0.001);两组不良反应发生率、不良妊娠结局比较,差异无统计学意义(P>0.05)。结论对妊娠期高血压疾病患者实施硫酸镁联合酚妥拉明及硝苯地平治疗,能够改善BNP、Cys C、D-D水平,提高疾病控制率。Objective To explore the effect of phentolamine,magnesium sulfate,and nifedipine on serum type B natriuretic peptide(BNP),cystatin C(CysC),and D dimer(D-D)in patients with pregnancy-induced hypertension(PIH).Methods A total of 500 patients with PIH were selected and divided into 2 groups according to the treatment methods.Two hundred and fifty cases in the observation group were treated with triple medication(phentolamine,magnesium sulfate,Nifedipine),and 61 cases in the control group with magnesium sulfate combined with nifedipine.Both groups were treated for 7 days,and the changes of BNP,CysC,D-D,serum creatinine,and hemodynamic levels(blood cell ratio,blood viscosity,resistance index,systolic to diastolic blood pressure ratio)before and after treatment were compared.The remission rate and the incidence of adverse reactions were compared between the two groups.Results Compared with the data before treatment,7 dCys C,D-D,Scr,BNP,blood ratio,blood viscosity,resistance index,SBP to diastolic BP ratio were significantly reduced after treatment(P<0.05).CysC,D-D,Scr,BNP,blood cell ratio,blood viscosity,resistance pressure ratio in the control group were lower than those in the the observation group(P>0.05),and serum CysC,D-D,Scr,BNP,blood cell ratio,blood viscosity,resistance index,systolic and diastolic blood pressure were lower on d7 than those of the control group(P<0.05).The disease response rates in the observation group on d1,d3,and d7 after treatment were higher than those in the control group(χ^(2)=25.194,24.754,26.699;P<0.001).There was no statistical difference in the incidence of adverse reactions and adverse pregnancy outcomes in the two groups(P>0.05).Conclusion The treatment of magnesium sulfate combined with phentolamine and nifedipine in patients with PIH can improve the levels of BNP,Cys C,D-D,and improve the disease control rate.

关 键 词：硫酸镁 酚妥拉明 硝苯地平 妊娠期高血压疾病 B型利钠肽 胱抑素C D二聚体 

分 类 号：R453[医药卫生—治疗学]