香丹注射液联合尼可地尔治疗冠心病稳定型劳力性心绞痛的疗效  

Therapeutic effect of Xiangdan injection combined with nicorandil in treating stable angina pectoris in patients with coronary heart disease

作　　者：高海军 陈永 李培 娄国梁 查远琼 吴琴 袁敏 GAO Haijun;CHEN Yong;LI Pei;LOU Guoliang;ZHA Yuanqiong;WU Qin;YUAN Min(Department of Internal Medicine,Posts and Telecommunications Hospital of Guizhou Provincial People's Hospital,Guiyang 550001,Guizhou,China;Department of Rheumatology,the Second Clinical School of Jinan University&Shenzhen People's Hospital,Shenzhen 518000,Guangdong,China;Department of cardiology,the Affiliated Hospital of Guizhou Medical University,Guiyang 550001,Guizhou,China)

机构地区：[1]贵州省人民医院邮电医院内科,贵州贵阳550001 [2]暨南大学第二临床医学院&深圳市人民医院风湿科,广东深圳518000 [3]贵州医科大学附属医院心内科,贵州贵阳550001

出　　处：《贵州医科大学学报》2023年第8期986-992,共7页Journal of Guizhou Medical University

基　　金：中国博士后科学基金项目(2021M701438)。

摘　　要：目的探讨香丹注射液联合尼可地尔治疗冠心病稳定型劳力性心绞痛患者的疗效。方法76例冠心病稳定型劳力性心绞痛患者随机均分为观察组(香丹注射液+尼可地尔片)和对照组(香丹注射液+单硝酸异山梨酯片);收集两组患者的基础资料,比较两组治疗效果,采用心脏彩色多普勒超声检测两组患者左心室射血分数(EF值),采用西雅图心绞痛量表(SAQ)测评心绞痛评分;采集两组患者治疗前后清晨空腹静脉血,检测血液黏度、同型半胱氨酸(HCY)以及脑钠肽(BNP)水平。结果治疗后观察组冠心病稳定型劳力性心绞痛患者有效率(94.7%)高于对照组(73.7%),差异有统计学意义(P<0.05);治疗后观察组患者EF值及SAQ评分均高于对照组,差异有统计学意义(P<0.05);治疗后观察组冠心病心绞痛患者低切、中切、高切黏度及HCY、BNP指标均低于对照组,差异有统计学意义(P<0.05);两组冠心病稳定型劳力性心绞痛患者不良反应率比较,差异无统计学意义(P>0.05)。结论香丹注射液联合尼可地尔治疗冠心病稳定型劳力性心绞痛患者的临床疗效较好,可有效缓解心绞痛发作,改善EF及SAQ评分,其机制可能与降低血液黏稠度、HCY及BNP水平有关。Objective To explore the therapeutic efficacy of Xiangdan injection combined with nicorandil in treating stable angina pectoris in patients with coronary heart disease.Methods A total of 76 patients with stable angina pectoris caused by coronary heart disease were randomly divided into an observation group(Xiangdan injection+nicorandil tablet)and a control group(Xiangdan injection+isosorbide mononitrate tablet).The baseline data of two groups were documented.The therapeutic efficacies were compared between two groups.Cardiac color Doppler ultrasound was applied to detect left ventricular ejection fraction(EF value)of two groups.Seattle Angina Questionnaire(SAQ)was used to evaluate angina score.Fasting morning venous blood from two groups before and after treatment were collected and used to measure blood viscosity and the levels of homocysteine(HCY)and brain natriuretic peptide(BNP).Results After treatment,the effective rate of stable angina pectoris patients in observation group was higher than that in control group(94.7%versus 73.7%,P<0.05).After treatment,EF values and SAQ scores of observation group were higher than those of control group(P<0.05).After treatment,the low shear-,medium shear-and high shear-blood viscosity,HCY,and BNP in observation group were lower than those in control group(P<0.05).There was no statistically significant difference in the adverse reaction rates between the two groups(P>0.05).Conclusion Xiangdan injection combined with nicorandil exhibits a good clinical efficacy in treating stable angina pectoris in patients with coronary heart disease,effectively alleviate the onset of angina pectoris and improve EF and SAQ scores.Its mechanism may be related to reducing blood viscosity,HCY,and BNP.

关 键 词：冠心病 心绞痛 香丹注射液 尼可地尔片 单硝酸异山梨酯片 射血分数 血流流变学 同型半胱氨酸 脑钠肽 西雅图心绞痛量表 

分 类 号：R541.4[医药卫生—心血管疾病]